Wen | amino observation

In the world of innovative medicine, the most important thing is the story of subversion.

From Baekje Shenzhou to Hengrui Pharma, it became the first innovative medicine, and then to the strong rise of domestic CAR-T and ADC, subversion continued.

In the innovative medicine camp, a group of unscrupulous pharmaceutical companies have even begun to make medicines. This may be subversive.

For example, Bailey Tianheng, which was born at the end of last year, set the world’s largest BD for ADC with a total transaction volume of 83 US dollars. People are surprised that a small imitation pharmaceutical company in Sichuan can also make a unique pipeline in the world?

For another example, Xiangxue Pharmaceutical, which has been popular recently, and the TCR-T therapy TAEST16001 developed by its subsidiary Xiangxue Life Sciences have been included in the list of breakthrough therapeutic varieties, and it is expected to become the first TCR-T listed. Xiangxue Pharmaceutical has also transformed from an old Chinese patent medicine enterprise into a leading company of advanced cell therapy, but the skyrocketing under the hype has come and gone quickly.

There are many incredible people, ideas and technologies in the field of innovative drugs, as well as a lot of hype. Therefore, the sense of separation and subversion is also increasing day by day.

However, the hype belongs to the hype, and the industry belongs to the industry. How is Xiangxue Pharmaceutical made? Behind this, how should we treat "innovation"?

01 innovative drugs are the most subversive.

When innovation becomes the main theme of the industry, transformation has become a top priority for all traditional pharmaceutical companies.

However, the opposition between tradition and innovation, and the gap between imitation and originality, most people think that traditional pharmaceutical companies have fallen behind, and no matter the size of enterprises, including big brother Hengrui Pharma, it is inevitable to ask: how can a generic drug maker make innovative drugs?

In particular, the listing of domestic PD-1 in 2018 and the opening of the two major exchanges to unprofitable biopharmaceutical companies, the whole capital and industry side, together pushed the innovative drug industry to the peak, and the field of innovative drugs was no different for a while, while traditional pharmaceutical companies once became the most desolate existence.

In fact, in the field of innovative drug research and development, traditional pharmaceutical companies have been slow, but it does not mean that they have completely lost opportunities.

Therefore, with the development of time, the transformation of some big pharmaceutical companies, such as Hengrui Pharma, Hansen Pharmaceutical and Unacon, is not smooth sailing, but it is natural because they have money and resources.

Subversion began when Baekje Shenzhou surpassed Hengrui and became the first brother of innovative medicine.

In 2022, the revenue of innovative drugs of the former surpassed that of the latter for the first time. This means that the leader of the domestic innovative drug market has changed hands. The young Baekje Shenzhou is still soaring, and its overall revenue may soon surpass that of Hengrui Pharma.

A number of new biotech faces have also begun to emerge. For example, in the emerging field of small nucleic acid drugs, Bowang Pharmaceutical, established in 2021, reached a cooperation with Novartis with a down payment of 185 million US dollars and a potential transaction of 4.165 billion US dollars to jointly develop a variety of cardiovascular siRNA drugs;

Yilian Bio, established in 2020, has successively reached cooperation with Roche and BioNTech with the story of its new generation ADC.

The research and development achievements of a new generation of biotech began to appear, which was expected by the market, because they were born for innovation.

The real subversion may be that a group of unscrupulous pharmaceutical companies have even begun to make medicines.

There was Bai Li Tian Heng, who was born in 2023. On December 12th, BL-B01D1, a dual-antibody ADC drug developed by Bailey Tianheng, was license out to Bristol-Myers Squibb with a total transaction amount of up to $8.3 billion.

This not only set a down payment record for the domestic innovative drug license out transaction, but also set a new record for the total price of the global ADC single drug transaction.

Who is Bai Li Tian Heng? Prior to this, its label was more "a Sichuan imitation pharmaceutical company".

Later, Xiangxue Pharmaceutical, the leader of A-share new cell therapy, rose by 227.5% in 11 trading days with the first overseas TCR-T therapy listed.

TAEST16001 injection developed by its subsidiary Xiangxue Life Sciences has been included in the list of breakthrough therapeutic varieties, and it is expected to become the first TCR-T cell therapy drug listed in China.

Who is Xiangxue Pharmaceutical? Prior to this, its label was more "anti-infective Chinese patent medicine enterprises". But this time, Xiangxue’s logic has changed, from an old Chinese patent medicine company to a leading company in advanced cell therapy.

Looking back, how did Xiangxue Pharmaceuticals make it?

How are the fragrant snows tempered?

Let’s look at Xiangxue Pharmaceutical first.

As an old Chinese medicine enterprise, it has neither the abundant internal resources of other big pharmaceutical companies nor the financial resources bought by buy buy willfully. How did a company relying on Chinese herbal medicines and oral liquid win the first domestic TCR-T therapy crown?

The story will start in 2012. At that time, Li Yi, a big cow in the field of cellular immunotherapy, returned to China to join the Guangzhou Institute of Biomedicine and Health of the Chinese Academy of Sciences and established a research platform, but he still needed to find a company to land.

When Li Yi worked in Avidex founded by Oxford University, he invented the guided evolution technology of TCR and used it to isolate and optimize the world’s first human-derived soluble TCR with high affinity, which opened the way for TCR to move from scientific research to clinical practice. Thanks to this key technological breakthrough, Immuncore, the leading company of TCR-T, has gradually developed from an early biotechnology company hatched by Oxford University to a company with multiple clinical products.

After returning home, by chance, Li Yi met Wang Yonghui, chairman of Xiangxue Pharmaceutical, and the two agreed to set up a life science research center and jointly establish a laboratory within Xiangxue Pharmaceutical.

Since 2013, Xiangxue Pharmaceutical has recruited scientists headed by Li Yi and Gong Haiping, which led to Xiangxue Life Science, which later became TCR-T.

In external reports, Xiangxue Pharmaceutical paid a price of 180 million yuan in five years for the promotion of TCR-T project. Among them, TAEST16001 has made the fastest progress. According to the wall newspaper data presented at this year’s ASCO meeting, as of April 2024, eight subjects were selected into the phase II clinical trial of TAEST16001, with the best remission rate of 50% and the median progression-free survival (mPFS) of 5.9 months.

From an industry perspective, the leading TCR-T company Immunocore, Adaptimmune, which just promoted the world’s first TCR-T therapy to be listed at the beginning of the month, and Xiangxue Life Sciences, the research and development teams of these three companies were actually one more than 10 years ago, that is, Avidex, where Li Yi worked.

From this point of view, several TCR-T products that are currently in the front line are only a few technologies transformed from the academic circles at that time, and they have landed in different countries and enterprises at the same time.

TCR-T is similar to CAR-T in mechanism. Compared with CAR-T, TCR is more similar to natural T cells in human body (CAR is only a fragment), which is not only safer, but also transmits stimulation signals to cells through TCR-CD3 complex. Therefore, TCR-T can not only identify antigens on tumor surface, but also identify antigens inside tumor. Therefore, TCR-T is more suitable for the treatment of solid tumors.

Even if it is a promising field, it needs practical results to prove its value. CAR-T therapy is widely known, largely thanks to successful cases like Emily’s, and then a variety of products have been listed one after another, opening a new era of cell therapy.

Although TCR-T therapy has great potential in theory, there is no product that really stands firm in the market.

Back to 12 years ago, not many companies were willing to spend hundreds of millions of dollars and continue to transfuse blood every year to bet on a track with uncertain future. Xiangxue has paid a lot for this. At present, the debt ratio of the company exceeds 70%, which is much higher than that of its peers such as Jichuan Pharmaceutical, which is about 20%.

Let’s look at Bai Li Tian Heng again.

Its development history can be traced back to 1996, when it started as a generic drug. At that time, Baili Tianheng’s predecessor, Baili Pharmaceutical, was established. Under the leadership of its founder, Yi Zhu, it launched the first generic drug, ribavirin granules, which once became a big single product.

Yi Zhu’s career is also "unusual". He majored in radio science, and later he got a master’s degree in biophysics from Fudan University and a doctor’s degree in corporate finance from Sichuan University. I have done real estate, set up Baili Pharmaceutical, and after taking the generic route, I took the sales team to fight in the front line.

Under the influence of drug quantity procurement and consistency evaluation, the company’s generic drug business revenue has been declining year by year, and the losses have been increasing. No one will believe that such a generic pharmaceutical company will make a name for itself in the field of innovative drugs. So, after the announcement of its deal with BMS, some people asked, who is Bailey Tianheng?

As early as 2008, Yi Zhu began to dabble in innovative drugs. Regrettably, after several years of tossing, many projects all failed.

However, he did not give up making innovative drugs. In 2014, he established an innovative pharmaceutical company in Seattle, Systimune. Ltd, which focused on the research and development of tumor drugs, and set up a research and development team.

At that time, Yi Zhu wrote a manuscript of the company’s plan for the next ten years: double antibodies, multi-antibodies and ADC drugs. At that time, the listing of TDM1 did not attract the attention of the industry. ADC drugs were at a low point in the United States, but he proposed to do double-antibody ADC.

It is believed that the toxicity problem of monoclonal antibody ADC has not been solved for the time being, and the uncertainty of dual antibody ADC will only be higher. However, Yi Zhu believes that technical problems can be solved, and it only takes time and investment: if there is a risk, strengthen the risk tolerance; If the resources are not enough, then think about how to get them back.

In June, 2023, Bailey Tianheng reported the first human clinical phase I research data of BL-B01D1 at ASCO meeting. BL-B01D1, which was not optimistic in 2014, was developed by Bailey Tianheng.

The results showed that the overall ORR was 45.3% when the median follow-up was 4.1 months, including 63.2% for EGFR mutant NSCLC, 44.9% for EGFR wild-type NSCLC and 53.6% for NPC patients.

It is such data that has contributed to its cooperation with BMS.

03 Tear off the "label"

In the eyes of the market, there may be only one truly smooth path for the transformation of generic pharmaceutical companies in China.

That is, to become a giant, after having a lot of resources, to acquire an already formed innovative drug system, or license in real innovative drugs, but most generic pharmaceutical companies are not enough.

The biggest argument for questioning the transformation of small-scale traditional pharmaceutical companies is that the development of new drugs abroad takes ten years and costs one billion dollars. A generic pharmaceutical company has a profit of only tens of millions of RMB a year. Why should it be a truly innovative drug?

Objectively speaking, such doubts are reasonable and normal. But it is this solidified way of thinking that increases the sense of separation and subversion in the field of innovative drugs.

For example, no matter Xiangxue Pharmaceutical or Baili Tianheng, we can see that the unscrupulous pharmaceutical companies can actually make innovative drugs.

Undeniably, there is a wave of speculation based on expectations behind Xiangxue Pharmaceutical’s stock price surge, and the clinical results are still unknown, and the skyrocketing speculation has come and gone quickly. In fact, its clinical data has also been questioned by some insiders, such as why the sample size is so small? How are 8 patients screened? Can you reproduce the same eye-catching data under the premise of increasing the number of overseas samples?

Everything has yet to be verified by time.

After the release of clinical data, Baili Tianheng was also questioned. When it reached a cooperation with BMS, it was regarded as a "dark horse" in the field of innovative drugs in China. It is also a medicine. After being endorsed by big pharmaceutical companies, the attitude of the market has changed rapidly.

Behind this, more is the role of "labels". Instead of directly judging the value of the drug itself, it is better to see who made it, who invested it and who bought it. Based on such a "label", it is easier to draw new and recognized conclusions.

Although it is important who made it and who bought it, even top researchers can’t violate the objective laws of the industry; Top multinational pharmaceutical companies can’t guarantee the success rate of every project and every transaction.

Perhaps, it is time for us to "label" thinking and treat "innovation" correctly.

In all fields, many times, things that others think can’t be done are not necessarily as difficult as they think. Just like the athletes who broke the monopoly of Europeans and Americans in this year’s Olympic Games, Pan Zhanle in swimming and queen Zheng Qinwen in tennis.

The same applies to the field of innovative drugs. There is no taking it for granted, and there is no impossibility. It is more a combination of necessity and accident.

Returning to the logic of innovative drug research and development, the achievements presented by Xiangxue Pharmaceutical and Baili Tianheng are, in essence, more a result of the innovative layout started 10 years ago; The key factor that determines how they will be three or five years later is the current layout and investment.

No matter whether it is biotech or traditional large pharmaceutical companies or small pharmaceutical companies, no one can succeed casually. It needs money, people and strategies, but also needs to advance and persist. What’s more, innovation is a divergent competition.

There is no absolute center for drug research and development, and the core depends on the efficacy of the product. The curative effect is determined by different principles and technical routes, and no one can monopolize and preset the results.

Because there is no fixed number of medicines.

　　CCTV News:After several months of investigation, the police in Xuanwei City, Yunnan Province recently destroyed an evil gang headed by the person in charge of the grassroots community. Recently, Yunnan police arrested seven suspects, including Qian Mou, deputy director of Liulin Community, in Liulin Community, Wanshui Street, Xuanwei City.

　　Chen Yuan, a policeman handling the case: "In 2017, from the end of June to the beginning of July, the public security organs kept receiving the person in charge of hauling coal ash from Xuanwei Power Plant, and went to the public security organs to report that their ash truck was blocked on the road many times and could not get into the power plant. Coal ash could not be pulled out. The most serious accident occurred in September, and the ash in ash storage has reached the warning line. If the ash is not pulled out in time, ash storage will explode, causing serious production accidents. "

　　Due to the urgency of the situation, Xuanwei City Public Security Bureau immediately set up a task force to investigate after receiving the alarm. After several months of in-depth and meticulous investigation, it was found that this seemingly simple contradiction and dispute between villagers and power plants actually hides a powerful behind-the-scenes pusher.

　　Chen Yuan, a policeman handling the case: "This incident was caused by Qianmou of Liulin Neighborhood Committee, who organized people to block the road for transporting coal and prevent the power plant from pulling coal ash to transport coal ash. His purpose is that the coal ash from the power plant can’t be pulled out, and then they organize people to pull it out and sell it to low-level cement plants to obtain certain economic benefits. "

　　There is a huge profit "black hand" hidden behind the coal ash waste residue.

　　Why do you want to organize people to compete for these humble coal ash residues? How much interest is there in it?

　　Chen Yuan, a policeman handling the case: "The total output of these coal ashes (from July to September, 2017) is about 20,000 tons, including the original water slag residue, which is 40,000 to 50,000 tons together. After he pulled all these things out and sold them, he gained more than one million economic benefits."

　　However, it is not a case that the power plant is blocked from production and operation like this. Zhang, who has worked in Xuanwei Power Plant for 20 years, told reporters that villagers in Liulin community and some unidentified people will come to block the power plant gates and office buildings from time to time, ranging from dozens to hundreds.

　　Xuanwei Power Plant Zhang: "Because of the historical reasons of our unit, the boundary is with their village. In this case, he often uses the excuse of pleading for the people to block the production and office area of the power plant. Their main person in charge put forward some exchange conditions for personal interests when talking about the project. For example, this problem of entering coal, taking engineering, and other things, as long as the power plant has contract business, he wants to do anything. "

　　Yang Tao, a policeman handling the case: "Through a large number of investigations in the early stage, we found that gangs headed by Qian Mou, in order to get the project from Xuanwei Power Plant and gain illegal benefits, incited people who didn’t know the truth to surround the gate of Xuanwei Power Plant for more than 40 times, blocked the normal traffic of vehicles in the area for more than 10 times, and disturbed the normal order for more than 20 times, which had a very bad impact on the normal production of enterprises and the lives of people around them."

　　The suspect admitted that the traffic jam was for economic benefit.

　　After the suspect arrived at the case, Xuanwei police conducted a trial according to law. At present, the suspect Qian confessed to the crime of blocking the power plant for profiteering.

　　Criminal suspect Qian: "We started to load the slag from the power plant at the end of June and load it to the cement plant. Because the water residue is waste, it has to be pulled to landfill. It is precisely the coal ash that falls on the coal yard and causes pollution. We thought that the power plant agreed to pull it anyway, and when it was pulled, there was a conflict of interest, and later a coal ash car was blocked. "

　　Inciting the masses to bully the city and village, involving many crimes.

　　With the advance of the trial, the criminal facts of this evil gang are becoming more and more clear. At present, there are still relevant criminal suspects coming to the case one after another. A further breakthrough has been made in the interrogation work. Combined with the investigation and evidence collection by the public security organs in the early stage, since October 2016, Qian has used his position to organize many people to manipulate security personnel in Liulin area, instructing villagers to make trouble and petition in the name of safeguarding the interests of the masses and representing their demands. Qian is mainly responsible for organizing, directing and leading a number of staff in Liulin community to bully the city within the community, and is suspected of intentional injury, destruction of production and operation, theft and other crimes, in which illegal income is kept by special personnel and used jointly by gang members.

　　Xu wen hua, a policeman handling the caseDuring the investigation, we also found that Liulin community recruited more than 40 idlers as security guards. These security guards were directly led and managed by Qian, deputy director of the neighborhood Committee. These security guards were not doing things for the people and protecting the safety of the people. They did whatever they wanted, and there were many incidents in which people were injured. One of the victims was still hospitalized. What’s worse, when the public security organs went to Liulin community to investigate and enforce the law, they not only did not cooperate, but even hindered the public security police.

　　victim: "I went home that night, and they were repairing the road. I discussed with them. My home arrived after this intersection, or I had to make a big detour. Can you let me pass, but the security guard disagreed? In the process of negotiation, a security guard rushed at me and threw me down. Then several people came up and beat me, and my leg was broken on the spot."

　　At present, seven suspects, including Qian, have been detained in criminal detention. It has been found that the gang is suspected of theft, sabotage of production and operation, and intentional injury, resulting in economic losses of millions of yuan. The case is still under further investigation.

　　Navigating for you in the ocean of information

　　China Radio International"China" series multilingual mobile clients are launched.

　　International Online Report (Reporter Yi Chengchen): On March 31st, three kinds of multilingual converged mobile clients "ChinaNews, ChinaRadio and ChinaTV" developed by China Radio International were released online. These three client products are characterized by multilingual and globalization, which can realize multilingual reading, listening and viewing, and provide intuitive, close and interactive all-media services for users around the world to understand China and the world. The release of "China" series of client products marks a new stage in the development of media convergence of China Radio International.

　　China Radio International, founded in December 1941, currently broadcasts to the world around the clock in 65 languages, making it the international communication organization with the largest number of languages in the world. In recent years, the international station has adhered to "multimedia integration and all-media development" and realized the transformation from external broadcasting to international communication.

　　In order to implement the spirit of the important speech of the Supreme Leader General Secretary, "Insist on advanced technology as the support and content construction as the foundation, and promote the deep integration of traditional media and emerging media in terms of content, channels, platforms, operation and management", and the central government’s media integration development strategy of "mobile priority", International TV follows closely the changes and development situation of international media, combines its own media characteristics, and integrates multilingual content resources around media construction and brand building to build an aggregated mobile. The "China" series of mobile client products released this time will rely on and strengthen the multilingual communication advantages of international stations to realize international communication based on the mobile Internet.

　　ChinaNews, a multilingual mobile news client, integrates the news resources of international stations, faces the international crowd, pushes hot news at home and abroad in real time by means of multilingual pictures, texts, videos and live broadcasts, interprets hot events from an authoritative perspective, and spreads the voice of China to the world with "first-hand information". It is a window for global users to pay attention to China and understand China, and it is also the spiritual home for overseas Chinese to love their motherland.

　　ChinaRadio, a multilingual mobile audio client, integrates multilingual audio program resources of international stations, takes multilingual audio programs as the main content and integrates multimedia communication means. This product is aimed at domestic and foreign users, providing live broadcast and on-demand services of multilingual radio programs, as well as various types of featured audio services covering information, music, entertainment, language learning and so on.

　　ChinaTV, a multilingual mobile video client, integrates video program resources of international stations, gathers cooperative media and third-party video news resources at home and abroad, and provides international news (video) reports and live video broadcasts of large-scale media activities for users all over the world. Gather multilingual video information content and broadcast programs of more than 300 domestic TV news programs, 140 live channels and three sets of digital TV channels (Global Shopping, Global Wonder and China Traffic Channel) of international TV stations; Show global quality documentaries, multilingual original videos produced by international stations and translated non-common language film and television programs. Strive to become a mobile video media window for overseas users to spread China culture.

On October 28, 2024, it was officially listed, and four models were launched, with the price range of 24,900 yuan to 39,900 yuan. At this conference, Pentium Pony cooperated with the well-known IP "Pony Baoli" for the first time, which attracted many women and children to participate in the interaction. This cross-border joint name is not only the first cooperation between Xiaoma Baoli and a car company, but also the first video joint name, which further enhances the attraction of the event.

The four models launched this time are: 122km cute horse, priced at 24,900 yuan; 170km energetic horse, priced at 31,900 yuan; 222km smart horse, priced at 36,900 yuan; And 222km lightning horse, priced at 39,900 yuan. In addition, Pentium Pony also announced a series of preferential policies for car purchase to attract more consumers.

Pony Baoli is a well-known IP for girls launched by Hasbro Company in 1980s. Its core concept revolves around dreams, creativity, kindness, courage and self-confidence. These images are highly compatible with the brand positioning of Pentium Pony. Pentium pony used many capsule lines in its design, incorporating the front and rear bumpers, the contrasting decorative parts of the side doors and the interior details. This design is inspired by the capsule car in the famous animation, and the Pentium pony shows the childhood dream in its unique way.

In terms of design, the Pentium pony abandoned the traditional square box design and adopted streamlined elements. The body size was 3000mm x 1510mm x 1630mm, and the overall shape was round and full, with smooth curves. The front face was designed with a contrast grille, which made it more lovely and attractive. In terms of interior, this new car adopts a "dessert"-like color scheme, and the layout of the shift knob is designed on the dashboard, so the user does not need to bow his head when operating, which is convenient and safe. At the same time, the brake pedal and the switch pedal are designed with music "pause" symbol and game "acceleration" symbol respectively, which adds interest.

In terms of battery life and performance, Pentium Pony also performed well, providing the longest battery life of 222km in its class, and upgrading the fast charging function, which can increase the battery life by 100km after charging for 1 hour. It is equipped with a 30kW high-power motor, which has stronger power performance and more flexible starting to meet the needs of daily travel.

Since its listing in May this year, Pentium Pony has continued to sell well, with sales exceeding 10,000 units in September, which is widely loved by trendy moms, fashionable women and families with children. With the price close to the people and relatively low maintenance cost, Pentium pony has become an ideal means of transportation for daily short-distance travel. If you are considering a scooter, Pentium Pony is undoubtedly a worthy choice.

　　China Economic Net Beijing September 30 th (Reporter) Guo Yue) Yesterday, the State Administration of Market Supervision announced five recalls of passenger cars, and five brands including Toyota, BYD, Link, BMW and smart will recall a total of 233,612 vehicles. Among them, only Toyota brand recalled more than 100,000 vehicles.

　　Specifically, among the five passenger car brands that initiated the recall, Toyota has the largest number, and will recall a total of 132,124 vehicles, namely, Fenglanda twin-engine and Corolla sharp-release twin-engine vehicles, accounting for 56.56% of the total recall on that day.

　　The reason for the recall of the two models is that the brake actuator can not properly adjust the brake fluid pressure when braking during steering due to the imperfect computer program for controlling the brake actuator. In extreme cases, it may cause the vehicle to fail to provide braking force according to the driver’s intention for a very short time, and the braking distance is longer than the driver’s predicted distance, which increases the risk of vehicle collision and has potential safety hazards.

　　In this regard, GAC Toyota Motor Co., Ltd. and FAW Toyota Motor Co., Ltd. will upgrade the internal program of the brake actuator control computer for vehicles within the recall range free of charge to eliminate potential safety hazards.

　　BYD recalled 96,714 dolphins and Yuan PLUS, accounting for 41.40%. The reason for the recall is that due to the manufacturing process of the electric power steering column assembly (CEPS) controller, the upper cover of the equipment tool interferes with the capacitor on the controller circuit board when it is closed, resulting in microcracks in the capacitor. When the vehicle is in use, the micro-cracks of the capacitor may expand and cause short circuit, resulting in overheating, ablation and even fire of the capacitor, which poses a safety risk.

　　In this regard, BYD Auto Industry Co., Ltd. and BYD Auto Co., Ltd. will entrust BYD authorized dealers to install controller insulation gaskets for vehicles within the scope of recall free of charge to eliminate potential safety hazards.

　　In addition, Lectra announced the recall of 2,539 Lectra 08 vehicles; BMW announced the recall of 1,264 imported 5 Series, 7 Series, i5 and i7 vehicles; Smart will recall 971 Elf #3 pure electric vehicles.

The answer to this question depends on your personal needs and preferences. The following are some advantages and disadvantages of the two types of vehicles for your reference:

Twin-engine vehicle (hybrid vehicle):

Advantages:

* High fuel efficiency, which can save fuel cost.

* Low emission and environmental friendliness.

* The driving experience is usually smoother and quieter.

Disadvantages:

* The purchase cost is relatively high.

* Maintenance costs such as regular battery replacement may also be high.

Pure oil vehicles:

Advantages:

* The purchase cost is relatively low.

* No battery maintenance problems.

* Easier to repair and maintain.

Disadvantages:

* Fuel efficiency is relatively low, which may increase fuel costs.

* The impact on the environment may be greater.

Considering the future trend and environmental protection requirements, hybrid vehicles may be more popular and have long-term investment value. However, if you are more concerned about the cost of car purchase and the convenience of maintenance, pure oil vehicles may be more suitable for you. Therefore, it is suggested that you make comprehensive consideration according to your own needs and budget, and choose the most suitable vehicle type.

　　Guangzhou Daily News (all-media reporter Ren Shanshan correspondent Yu Guangbiao) The hoarse voice has not improved for more than a month, not necessarily "getting angry", but more likely laryngeal cancer! If you smoke for a long time, you should be more alert to the risk of laryngeal cancer.

　　Recently, the first member congress of the professional committee of laryngopharyngeal cancer of Guangdong Clinical Medical Association and the second standardized diagnosis, treatment and new progress course of laryngeal and laryngopharyngeal cancer were held in Guangzhou. Professor Liu Xuekui, Chairman of the Professional Committee of Laryngolaryngeal Tumors of Guangdong Clinical Medical Association and Head and Neck Surgery of Cancer Prevention Center of Sun Yat-sen University, pointed out that in recent years, the incidence of laryngeal cancer has shown an increasing trend, ranking second among all head and neck tumors, and the incidence has shown a younger trend. He reminded that men who have a history of smoking and are over 40 years old should see a doctor as soon as possible and have an electronic laryngoscope examination once they have hoarseness for more than a month frequently, or if the heat-clearing and anti-inflammatory treatment according to pharyngitis does not work.

　　Liu Xuekui pointed out that the 5-year survival rate of early treatment of laryngeal cancer can reach more than 90%, and once it is diagnosed in the advanced stage, the survival rate will drop sharply. "Like many cancers, in China, when many patients with laryngeal cancer are diagnosed, they often reach the middle and late stage, and the treatment of advanced laryngeal cancer is still a problem." He reminded that patients with suspicious symptoms of laryngeal cancer should be examined by electronic laryngoscope. The examination cost of electronic laryngoscope is not high, and it is very convenient. Once you see a suspicious tumor in the throat, the doctor takes a sample for pathological examination, which is conducive to the early diagnosis.

　　At present, the clinical treatment methods for laryngeal cancer mainly include radiotherapy, surgical treatment, comprehensive treatment of radiotherapy and surgery. Generally speaking, the treatment of early laryngeal cancer is mainly surgery and radiotherapy, and comprehensive treatment is needed in the middle and late stage.

　　The traditional treatment mode of locally advanced laryngeal cancer is total laryngectomy plus postoperative radiotherapy, and the lesion is completely removed. The survival situation of patients is still optimistic. However, under this treatment mode, the function of larynx is often seriously damaged or even unable to be preserved, which affects the respiratory function and vocal function of patients and leads to poor quality of life.

　　In recent years, with the medical profession paying more and more attention to the quality of life of cancer patients, some doctors have proposed that the laryngeal function should be preserved as much as possible in the treatment of advanced laryngeal cancer, and radiotherapy and chemotherapy should be carried out first, and then surgical resection should be carried out if the effect is not good or the disease recurs.

　　Liu Xuekui pointed out that it is important to preserve laryngeal function, but it is more important to save the patient’s life first. Clinical practice shows that radiotherapy and chemotherapy are difficult to achieve good results in a considerable number of patients with laryngeal cancer. Under the treatment idea of "preserving function first", patients may miss the best opportunity for surgical resection and eventually fail to operate. "It is equivalent to that if the scheme of radiotherapy first and then surgery is not effective, the previous radiotherapy and chemotherapy will be wasted, and the radiotherapy and chemotherapy after surgery will be ‘ Remedy ’ The opportunity is also lost. " He believes that when deciding the treatment plan, doctors need to make careful choices, depending on the specific situation of patients.

　　It is worth mentioning that in recent years, Liu Xuekui innovatively used titanium mesh stent to reconstruct laryngeal function, which provided another safer, more reliable and economical treatment method for patients and brought good news to patients. At present, this new technology has won the national invention patent and has been adopted by many hospitals in China.

Kiritani mirei, Shohei Miura.

1905 movie network news According to Japanese media reports, kiritani mirei’s love affair with Shohei Miura was exposed. In 2016, the two performed the Japanese drama "People Who Like". In the play, kiritani mirei’s heroine, Miyuki Sakurai, has always had a crush on Shohei Miura’s Saizaki Chihiro, but they are not together in the end. Off-stage, the two leading actors finally got married.

In early December, kiritani mirei was photographed shopping in the supermarket near the apartment.

It is reported that kiritani mirei and Shohei Miura have recently started to associate, and they still live in the same apartment building and are neighbors. According to informed sources, the two have known each other for more than five years. At the time of filming "Someone You Like", Shohei Miura was in contact with actress Honda Tsubasa, but at that time they were already close friends at dinner. In the spring of 2017, after Shohei Miura and Honda Tsubasa broke up, the relationship with kiritani mirei, who had a good talk, warmed up.

Big S, Vic Zhou in and out of the play

Kiritani mirei wasn’t the only one who fell in love with Male No.2 outside the play.In 2001, Meteor Garden became an epoch-making classic in Taiwan Province’s idol drama. However, instead of having a love affair with Jerry Yan, Doumyouji Tsukasa, Big S started a sister-in-law relationship with Vic Zhou, the male No.2 in the drama.

Tang Yan and Luo Jin are in and out of the play.

Coincidentally, in the TV series, Tang Yan, who plays the heroine Mi Duo, is also a real lover with Luo Jin, who plays the spare tire man No.2 Lei Yiming.

Order of the National Bureau of Statistics

sequence　21　number

The Measures for the Supervision and Inspection of Statistical Law Enforcement have been discussed and passed at the 1st executive meeting of the National Bureau of Statistics on June 2, 2017, and are hereby promulgated and shall come into force as of September 1, 2017.

Director Ning Ji Zhe　　　　　　　　　　

July 5, 2017　　　　　　　　　　

Measures for supervision and inspection of statistical law enforcement

Chapter I General Principles

the first　In order to standardize the supervision and inspection of statistical law enforcement, protect the legitimate rights and interests of citizens, legal persons and other organizations, and ensure and improve the quality of statistical data, these measures are formulated in accordance with the Statistics Law of the People’s Republic of China, the Administrative Punishment Law of the People’s Republic of China and the Regulations for the Implementation of the Statistics Law of the People’s Republic of China.

the second　These Measures shall apply to the supervision and inspection of the statistical agencies of the people’s governments at or above the county level on the implementation of statistical laws, regulations and rules and the investigation and punishment of statistical violations.

Article　Under the leadership of the National Bureau of Statistics, the Bureau of Statistics Law Enforcement Supervision of the National Bureau of Statistics is specifically responsible for organizing and managing the supervision and inspection of national statistical law enforcement, guiding and supervising the work of local statistical agencies and statistical law enforcement supervision and inspection agencies of the national investigation team, inspecting the implementation of statistical laws in various localities and departments, and investigating major statistical violations.

Provincial and municipal statistical law enforcement supervision and inspection institutions, under the leadership of their respective statistical bureaus or national investigation teams, are specifically responsible for guiding and supervising the supervision and inspection of statistical law enforcement in their own regions and systems, inspecting the implementation of statistical laws in their own regions and systems, and investigating statistical violations. County-level statistical law enforcement supervision and inspection institutions or law enforcement inspectors shall, under the leadership of their respective statistical bureaus or national investigation teams, be responsible for the supervision and inspection of statistical law enforcement in their own regions and systems according to the legal division of labor.

Local statistical agencies and national investigation teams shall establish a communication and cooperation mechanism for statistical law enforcement supervision and inspection.

Article 4　The relevant departments of the people’s governments at or above the county level shall, under the organization and guidance of the statistical agencies of the people’s governments at the same level, be responsible for supervising the implementation of the statistical law in the statistical investigation of their own departments, and hand over statistical violations that occur in the statistical investigation of their own departments to the statistical agencies of the people’s governments at the same level for handling.

Article 5　The statistical agencies of the people’s governments at all levels shall establish the responsibility system and accountability system for the supervision and inspection of administrative law enforcement, and effectively guarantee the personnel, funds and other working conditions required for the supervision and inspection of statistical law enforcement.

Article 6　The supervision and inspection of statistical law enforcement should implement the principle of abiding by laws, strictly enforcing laws and prosecuting offenders, adhere to the combination of prevention, investigation and rectification, adhere to the combination of education and punishment, and adhere to the principles of seeking truth from facts, objectivity and fairness, unification and standardization, civilized law enforcement, high efficiency and honesty.

In the supervision and inspection of statistical law enforcement, people who have an interest in the object of law enforcement supervision and inspection and other personnel who may affect impartiality should be avoided.

Article 7　The statistical agencies of the people’s governments at or above the county level shall unblock the channels for reporting statistical violations, publish the telephone number, mailing address, network column and e-mail address of statistical violations, and seriously accept, verify and handle statistical violations.

Article 8　Statistical institutions of the people’s governments at or above the county level shall establish a reporting system for the investigation and handling of statistical violations, and regularly report statistical violations, statistical law enforcement supervision and inspection, and statistical violations.

Chapter II Supervision and Inspection of Statistical Law EnforcementInstitutions and law enforcement inspectors

Article 9　The statistical agencies of the people’s governments at or above the county level shall improve the supervision and inspection team of statistical law enforcement, improve the supervision and inspection mechanism of statistical law enforcement, establish the backbone talent pool of statistical law enforcement, and ensure that the personnel in the pool obey the call of the database establishment agency.

Article 10　The main responsibilities of statistical law enforcement supervision and inspection institutions and law enforcement inspectors are:

(1) Drafting and formulating statistical laws, regulations and normative documents;

(two) publicity and implementation of statistical laws and regulations;

(three) to organize, guide, supervise and manage the supervision and inspection of statistical law enforcement;

(four) to investigate and deal with statistical violations according to law, and to prevent and punish statistical fraud and fraud;

(five) organize the implementation of statistical law enforcement "double random" spot checks, accept, handle and supervise statistical illegal reports;

(six) establish and improve the statistical credit system, establish and implement the joint punishment mechanism for statistical fraud and fraud;

(seven) to supervise and investigate illegal activities in foreign-related statistical investigation activities and folk statistical investigation activities;

(eight) other duties as prescribed by laws, regulations and rules.

Article 11　Law enforcement inspectors shall participate in training and pass the examination, and obtain a statistical law enforcement certificate issued by the National Bureau of Statistics.

With the approval of the statistical agencies of the people’s governments at or above the county level, professional and technical personnel may be employed to participate in the supervision and inspection of statistical law enforcement.

Article 12　Statistical law enforcement supervision and inspection institutions shall strengthen the laws and regulations, statistical business knowledge, professional ethics education and law enforcement supervision and inspection skills training of their law enforcement inspectors, and improve the management, assessment and reward and punishment system.

Chapter III Supervision and Inspection of Statistical Law Enforcement

Article 13　The statistical agencies of the people’s governments at or above the county level and relevant departments shall establish the working mechanism and relevant system of statistical law enforcement supervision and inspection, and comprehensively use the methods of "double random" spot check, special inspection, key inspection and on-the-spot verification to organize the supervision and inspection of statistical law enforcement in their own regions, departments and units.

In accordance with the relevant provisions of the state, actively promote the statistical law enforcement supervision and inspection record system.

Article 14　Statistical law enforcement supervision and inspection items include:

(a) the local people’s governments at all levels, government statistical agencies and relevant departments, as well as all units and their responsible persons, abide by and implement statistical laws, regulations and rules and national statistical rules and decrees;

(two) the local people’s governments at all levels, government statistical agencies and relevant departments to establish a responsibility system and accountability system to prevent and punish statistical fraud;

(three) statistical agencies and statisticians independently exercise their functions and powers of statistical investigation, statistical report and statistical supervision according to law;

(four) the state organs, enterprises, institutions and other organizations, as well as individual industrial and commercial households and individuals and other statistical investigation objects to comply with statistical laws, regulations and rules, statistical investigation system;

(five) to carry out foreign-related statistical investigations and folk statistical investigations according to law;

(six) other matters stipulated by laws, regulations and rules.

Article 15　The statistical agencies of the people’s governments at or above the county level shall accept the reports received in strict accordance with the provisions. If there may be statistical violations after examination, they shall take measures to put on record for investigation and law enforcement inspection, and the statistical agencies of the people’s governments at or above the municipal level may also forward the reports to the statistical agencies at lower levels for handling in accordance with the provisions.

Article 16　The statistical agencies of the people’s governments at or above the county level shall, before organizing the implementation of the supervision and inspection of statistical law enforcement, draw up an inspection plan, and clarify the basis, time, scope, content and organizational form of the inspection.

Article 17　Statistical law enforcement supervision and inspection institutions or law enforcement inspectors shall report to the person in charge of the statistical institutions of the people’s government for approval before organizing the implementation of law enforcement supervision and inspection.

Article 18　The implementation of statistical law enforcement supervision and inspection shall inform the inspection object in advance, and inform the people’s government of the name of the statistical agency that implements the inspection, the basis, scope, content, method and time of the inspection, and the specific requirements for the inspection object.

Article 19　Statistical law enforcement supervision and inspection institutions to carry out law enforcement supervision and inspection, law enforcement inspectors shall not be less than 2, and shall produce a unified statistical law enforcement certificate issued by the National Bureau of Statistics, inform the inspection object and the relevant units of the relevant rights, obligations and corresponding legal responsibilities. If the statistical law enforcement certificate is not produced, the relevant units and individuals have the right to refuse to accept the inspection.

Article 20　The statistical agencies of the people’s governments at or above the county level shall exercise their functions and powers of supervision and inspection of statistical law enforcement in accordance with the provisions of Article 35 of the Statistics Law when investigating illegal acts or verifying statistical data.

Article 21　The object of inspection and the relevant units shall, in accordance with the provisions of statistical laws and regulations, actively cooperate with the supervision and inspection of law enforcement and provide necessary conditions for the inspection work. Relevant personnel shall truthfully answer inquiries, reflect the situation, provide relevant certificates and materials, verify the transcripts, and sign the relevant certificates, materials and transcripts, and affix the official seal of the units involved. Refusing to sign or seal, the law enforcement inspectors shall record the reasons on the spot and make audio and video recordings.

Relevant localities, departments and units shall promptly notify relevant personnel to accept the inspection as required.

Article 22　Statistical law enforcement supervision and inspection institutions shall, in the process of law enforcement supervision and inspection, make law enforcement documents in a timely manner according to regulations, truthfully record the inquiries made by law enforcement inspectors and the information reflected by the inspection objects, as well as the certificates and materials provided, and the law enforcement inspectors shall sign the relevant records.

Article 23　The statistical agencies and law enforcement inspectors of the people’s governments at or above the county level shall be obliged to keep confidential the state secrets, business secrets, personal information and materials that can identify or infer the identity of a single investigation object.

Article 24　The statistical law enforcement supervision and inspection institution shall, after the investigation, submit an inspection report to the statistical institution of the people’s government in a timely manner, report the problems found in the inspection and put forward suggestions.

Article 25　Statistical institutions of the people’s governments at or above the county level have found statistical violations, and should be investigated for legal responsibility according to law. Generally, they should be investigated and dealt with by the inspection organs, or they can be submitted to the statistical institutions of the people’s governments at the next higher level or handed over to the people’s governments at lower levels for investigation and handling according to the nature and circumstances of the violations.

Chapter IV Punishment of Statistical Violations

Article 26　The punishment of statistical violations shall be carried out in accordance with the following procedures: filing, investigating, handling and closing the case.

Article 27　To investigate and deal with statistical illegal cases, the facts should be clear, the evidence should be conclusive, the nature should be accurate, the handling should be appropriate, the applicable law should be correct, and legal procedures should be followed.

Article 28　The National Bureau of Statistics is responsible for investigating cases of statistical fraud and fraud with serious circumstances or bad influence, cases of ineffective implementation of major national statistical arrangements, serious statistical fraud and fraud cases in major national conditions and national strength surveys, and other major statistical violations.

Provincial statistical bureaus shall be responsible for investigating and handling cases of statistical fraud and fraud within their respective administrative areas, and cases that violate the national statistical investigation system and important local statistical investigation systems. However, cases of statistical fraud, fraud and violation of the national statistical investigation system in the statistical investigation organized and implemented by the National Investigation Corps shall be investigated and dealt with by the National Investigation Corps.

Municipal and county-level statistical bureaus and municipal and county-level investigation teams of the National Bureau of Statistics shall be responsible for investigating and handling statistical illegal cases within their respective administrative areas according to law.

Article 29　Statistical law enforcement supervision and inspection agencies are specifically responsible for investigating statistical violations, and the statistical law enforcement team accepts the entrustment of its subordinate statistical agencies to carry out relevant law enforcement inspections.

Article 30　For the following statistical violations, the statistical agencies of the people’s governments at or above the county level shall file a case according to law:

(a) all localities, departments and units and their responsible persons violate statistical laws, regulations and rules;

(two) the statistical agencies of the people’s governments at or above the county level and their staff violate statistical laws, regulations and rules;

(three) state organs, enterprises, institutions and other organizations, as well as individual industrial and commercial households and other survey objects in violation of statistical laws and regulations;

(four) in violation of national statistical rules and decrees;

(5) Violating the relevant laws, regulations and rules of foreign-related statistical investigation and folk statistical investigation;

(six) other cases that should be filed in accordance with the provisions of laws, regulations and rules.

For statistical violations found in the supervision and inspection of statistical law enforcement and clearly investigated, if it is necessary to file a case for investigation, it shall be added.

Article 31　The statistical violations investigated and dealt with shall meet the following conditions at the same time:

(a) there is a clear actor;

(two) in violation of the provisions of article thirtieth of the act, shall be investigated for legal responsibility according to law;

(three) belong to the people’s government statistical agencies responsibilities and jurisdiction.

Statistical law enforcement supervision and inspection institutions shall, in accordance with the conditions stipulated in the preceding paragraph, conduct a preliminary examination of the relevant materials to be filed, fill in the Approval Form for Filing a Case, and submit it to the person in charge of the statistical institution of the people’s government for approval before filing a case.

Article 32　If a case is decided to be put on file for investigation, an investigation shall be organized in time. There shall be no less than 2 law enforcement inspectors in general cases, and a law enforcement inspection team shall be formed in major cases according to regulations.

Article 33　Law enforcement inspectors shall collect evidence legally, objectively and comprehensively. In the process of collecting evidence, law enforcement inspectors shall make on-site inspection records, investigation records and other documents in a timely manner, and sort out and make the Evidence Registration Form.

The evidence of the case shall be related to the case, including documentary evidence, physical evidence, electronic data, audio-visual materials, witness testimony, statements of the parties, expert conclusions, records of inquests and other materials that can prove illegal facts.

Article 34　After the investigation, the law enforcement inspection team or law enforcement inspectors shall form an investigation report in time and submit it to the person in charge of the statistical agency of the people’s government.

The contents of the inspection report include: filing basis, inspection situation, illegal facts, legal basis, illegal nature, legal responsibility, discretionary circumstances, handling opinions, etc.

Article 35　The statistical law enforcement supervision and inspection institution shall organize a meeting in time to discuss and hear the case, determine the nature of the statistical illegal act and the decision to deal with it, and report it to the person in charge of the statistical institution for review. If the circumstances are complicated or major illegal acts are given heavier administrative punishment, it should be decided through collective discussion.

In the course of the trial, if it is found that the statistical illegal facts are unclear, the evidence is insufficient or the procedure is wrong, it shall instruct the statistical law enforcement supervision and inspection institutions or law enforcement inspectors to supplement or re-investigate in time.

Article 36　At the end of the trial of statistical illegal cases, the following situations shall be dealt with respectively:

(1) If there is insufficient evidence of violation of statistical laws, regulations and rules, or if the facts of statistical violations are minor, legal responsibility should not be investigated according to law, that is, a marketing case;

(two) in violation of statistical laws and regulations, the facts are clear and the evidence is conclusive, and it shall be dealt with according to law;

(three) in violation of statistical laws and regulations and national statistical rules and decrees, should be punished, transferred to the appointment and removal organs or discipline inspection and supervision organs;

(four) in violation of statistical laws and regulations and national statistical rules, government decrees, was identified as a serious breach of trust in statistics, publicity and punishment in accordance with the relevant provisions of the state;

(five) suspected of violating other laws and regulations, handed over to the relevant administrative organs;

(six) suspected of committing a crime, transferred to judicial organs.

Article 37　Statistical illegal facts are clear and the evidence is conclusive, and it is decided to impose administrative punishment according to law. Before making the decision on administrative punishment, a Notice of Statistical Administrative Punishment Decision shall be made to inform the object of punishment of the facts, reasons, basis and rights enjoyed by the object of punishment according to law. When the object of punishment makes statements and arguments on the punishment decision and puts forward different opinions, the statistical law enforcement supervision and inspection institutions shall listen carefully. The punishment object puts forward new facts, reasons and evidence, and the statistical law enforcement supervision and inspection institution shall conduct a review. If the review is established, it shall be adopted.

Article 38　Before the statistical agencies of the people’s governments at or above the county level make a decision on administrative punishment of a legal person or other organization with a fine of more than 50,000 yuan, or an individual industrial and commercial household with a fine of more than 2,000 yuan, they shall inform the object of punishment of the right to request a hearing. If the object of punishment requests a hearing, the statistical agency that made the decision on punishment shall organize a hearing according to law.

The object of punishment shall, within 3 days after receiving the Notice of Statistical Administrative Punishment Decision, put forward a hearing request to the statistical institution that made the punishment decision, and the statistical institution that made the punishment decision shall notify the object of punishment of the time and place of the hearing 7 days before the hearing.

The hearing shall be presided over by non-law enforcement inspectors designated by statistical agencies. If the object of punishment thinks that the moderator has a direct interest in the case, he has the right to apply for withdrawal. When holding a hearing, the law enforcement inspectors put forward the facts, evidence and punishment suggestions of the object of punishment, and the object of punishment defended and cross-examined. A written record shall be made for the hearing, and the written record shall be signed or sealed by the object of punishment after examination and verification.

After the hearing, the statistical agency shall make a decision on punishment in accordance with Article 36 of these Measures.

Article 39　Statistical violations should be given administrative punishment, make a decision on punishment according to law, and make a decision on statistical administrative punishment. The Decision on Statistical Administrative Punishment shall specify the following items:

(a) the name or name and address of the object of punishment;

(2) Facts and evidence that violate statistical laws, regulations and rules;

(three) the types and basis of statistical administrative punishment;

(four) the way and time limit for the performance of statistical administrative punishment;

(five) the way and time limit for applying for administrative reconsideration or bringing an administrative lawsuit against the decision of statistical administrative punishment;

(six) the name of the statistical agency that made the decision on statistical administrative punishment and the date of making the decision.

The decision on statistical administrative punishment must be stamped with the seal of the statistical institution that made the decision on statistical administrative punishment.

Article 40　The statistical agencies of the people’s governments at or above the county level shall deliver the punishment object within 7 days after the decision on statistical administrative punishment is made. The object of punishment shall sign and seal the receipt of service, and indicate the date of receipt. If the object of punishment refuses to accept it, it shall be witnessed by other personnel, and the service personnel and witnesses shall sign the receipt of service and indicate the reasons, and retain the Decision on Statistical Administrative Punishment; If the object of punishment cannot be accepted, it shall be witnessed by other personnel, and the service personnel and witnesses shall sign the receipt and indicate the reasons.

If it is delivered by post, it shall be sent by registered post in China.

Article 41　After the decision of statistical administrative punishment is made, the object of punishment shall be fulfilled within the time limit of the decision of statistical administrative punishment. If the object of punishment refuses to accept the decision on statistical administrative punishment, applies for administrative reconsideration or brings an administrative lawsuit, the statistical administrative punishment shall not be suspended.

Statistical law enforcement supervision and inspection institutions shall timely grasp the implementation of statistical administrative punishment.

Article 42　Statistical violations investigated and dealt with shall be handled within 3 months after the case is filed; If it is necessary to extend the processing period due to special circumstances, it shall be reported for approval according to regulations, but the extension period shall not exceed 3 months.

Article 43　If the statistical illegal facts are clear and have a legal basis, and a legal person or other organization is given a warning or a warning and imposed an administrative penalty of a fine of not more than 1000 yuan, a summary punishment procedure can be applied and a decision on statistical administrative penalty can be made on the spot.

Article 44　After the implementation of the decision on handling statistical violations, the case shall be closed in time.

The closing report shall be written and submitted to the person in charge of the statistical agency of the people’s government for approval, and the case shall be closed.

Article 45　Statistical institutions of the people’s governments at or above the county level shall, when investigating and handling statistical illegal cases, put forward suggestions for punishment in accordance with relevant regulations, and transfer the case materials and suggestions for punishment to the appointment and removal organ or discipline inspection organ, supervision organ and organization (personnel) department with jurisdiction.

Article 46　Those who have serious statistical fraud shall be deemed as statistically serious dishonesty according to law, and shall be publicized and punished in accordance with relevant regulations.

Chapter V Legal Liability

Article 47　People’s governments at or above the county level statistics institutions responsible person, law enforcement inspectors and related personnel in the statistical law enforcement supervision and inspection has one of the following acts, shall be informed by the statistics institutions, and shall be punished by the appointment and removal organ or the discipline inspection and supervision organ:

(a) shielding and conniving at statistical violations;

(two) the case is not reported, and the case is not investigated;

(three) failing to accept, verify and deal with statistical illegal reports according to regulations;

(four) failing to carry out statistical law enforcement supervision and inspection according to the statutory authority, procedures and requirements, resulting in adverse consequences;

(five) in violation of confidentiality provisions, disclosure of informants or the case;

(six) abuse of power, favoritism;

(seven) other violations of discipline and law.

Article 48　Persons in charge of statistical agencies of the people’s governments at or above the county level, law enforcement inspectors and their related personnel who violate relevant disciplines in the supervision and inspection of statistical law enforcement shall be punished according to discipline.

Article 49　The person in charge of the statistical agencies of the people’s governments at or above the county level, law enforcement inspectors and their relevant personnel shall be punished according to discipline and law if they disclose state secrets, business secrets, personal information and materials that can identify or infer the identity of a single investigation object.

Chapter VI Supplementary Provisions

Article 50　These Measures shall come into force as of September 1, 2017. "Statistical law enforcement inspection regulations" shall be abolished at the same time.

　　On Thursday (November 28th) EST, the US stock market and the US debt market were closed for Thanksgiving Day. On Friday, the day after Thanksgiving, the US stock market will close three hours earlier, that is, at 2: 00 a.m. the next day Beijing time. European stocks rose, and the STOXX 600 index in Europe closed up 0.46%. Germany DAX 30 index closed up 0.85%. The French CAC 40 index closed up 0.51%. Britain’s FTSE 100 index closed up 0.08%.

[global index]　

[China index]　

　　On November 28th, the Hang Seng Technology Index futures fell 1.39% overnight, and the FTSE China A50 index fell 0.85%.

[foreign exchange commodities]　

[Global News]　

　　Biden: I hope Trump will reconsider the plan to impose tariffs on Mexico and Canada.

　　According to CCTV news, on November 28th, local time, US President Biden expressed the hope that President-elect Trump would reconsider his plan to impose tariffs on Mexico and Canada, saying it might "destroy the relationship with close allies". Biden said that the United States is surrounded by Mexico, Canada, the Pacific Ocean and the Atlantic Ocean, and the last thing it should do is to undermine its relations with Mexico and Canada.

　　Putin: If Uzbekistan acquires nuclear weapons, Russia will use all available means of attack.

　　According to CCTV news, Putin held a press conference after his visit to Kazakhstan. On the conflict between Russia and Ukraine, Putin said that Russia will not allow Ukraine to possess nuclear weapons, and if Ukraine acquires nuclear weapons, Russia will use all available means of attack. Putin reiterated that Russia can use the Hazelnut missile to attack Ukraine’s decision-making center. Putin also said that after Russia used the "hazel tree" missile system, the Ukrainian side used US Army tactical missiles to attack Russia twice. The Russian loss is small, but the loss exists. Russia will respond, how, when and what kind of weapon to use will depend on the target chosen by the Russian General Staff. Russia’s principled position on resolving the Ukrainian crisis has not changed. Russia is open to the negotiation process, and it is still based on the conditions mentioned during Putin’s meeting with the leadership of the Russian Foreign Ministry in June this year. As for special military operations, Putin said that the General Staff of the Russian Armed Forces and the Russian Ministry of Defense are considering listing UAV units as separate arms.

　　European Central Bank President Lagarde: It is suggested that the EU purchase more American natural gas to avoid Trump trade conflict.

　　European Central Bank President Lagarde stressed that the EU should adopt the strategy of "negotiation" rather than "retaliation" to resolve the tariff dispute with the Trump administration, warning that fierce trade conflicts will damage global economic growth. She suggested that the EU buy more American goods such as LNG from the United States to reduce direct conflicts and promote cooperation. She said that if the EU negotiates with the United States on potential trade tariffs instead of taking countermeasures immediately, it may put the EU in a more favorable position.

　　The first 5-day X23-hour exchange of US stocks is getting closer and closer to being approved for all-weather trading.

　　Exchange became the first national stock exchange in the United States that can trade 23 hours a day, 5 days a week. With the increasing interest in all-weather trading in the US stock market, NYSE Arca and Robinhood under NYSE are also eager to try.

　　Musk announced the "layoff list" and US federal officials "everyone is in danger"

　　Under the premise of uncensored, Musk personally threatened officials by exposing their personal information on social media platforms, which led to the resignation of the parties. According to the analysis, through this alternative layoffs, Musk is sending a signal to all government agencies: either quit, or the next (exposed) is you.

　　OpenAI: Enterprise IT expenditure is undergoing a "paradigm shift" and shifting to a generative AI.

　　The sales director of OpenAI believes that the artificial intelligence expenditure of enterprises has undergone a "paradigm shift", the IT budget of enterprises is shifting sharply to generative AI, and the customer base of OpenAI has shifted from start-ups to traditional industries such as medical care, manufacturing and retail.

　　The sharp decline in the valuation of X has caused investors to lose blood. Musk is said to have provided xAI shares to compensate.

　　XAI raised $5 billion in the latest round of financing, and its valuation reached $50 billion. According to people familiar with the matter, in the two rounds of financing, X investors obtained a quarter of the shares of xAI, and the shares issued by this new financing did not dilute their shareholding ratio. In September this year, an investment institution said that the valuation of X has shrunk to 9.4 billion US dollars, which is nearly 80% lower than the purchase price.

　　The game of delaying production reduction and increasing production in OPEC official announcement meeting has intensified.

　　On Thursday (November 28th) local time, the Vienna-based Organization of Petroleum Exporting Countries (OPEC) announced in official website that two meetings related to the oil production plan were postponed for four days. The day before, energy officials from Saudi Arabia, Russia and Kazakhstan emphasized maintaining the stability and balance of the global oil market and "fully promised to abide by mutual agreements".

　　The Lancet’s latest research: A historic breakthrough in the treatment of asthma and chronic obstructive pulmonary disease.

　　According to a study published in The Lancet magazine, Benalizumab injection is more effective than steroid tablets in treating asthma and chronic obstructive pulmonary disease, which can reduce the number of follow-up treatments for patients. This is the first new treatment for patients with asthma and chronic obstructive pulmonary disease in 50 years. Benalizumab is a kind of anti-inflammatory drug developed by AstraZeneca in the United States, which can directly, quickly and almost completely remove eosinophils within 24 hours to reduce lung inflammation.