Wen | amino observation

In the world of innovative medicine, the most important thing is the story of subversion.

From Baekje Shenzhou to Hengrui Pharma, it became the first innovative medicine, and then to the strong rise of domestic CAR-T and ADC, subversion continued.

In the innovative medicine camp, a group of unscrupulous pharmaceutical companies have even begun to make medicines. This may be subversive.

For example, Bailey Tianheng, which was born at the end of last year, set the world’s largest BD for ADC with a total transaction volume of 83 US dollars. People are surprised that a small imitation pharmaceutical company in Sichuan can also make a unique pipeline in the world?

For another example, Xiangxue Pharmaceutical, which has been popular recently, and the TCR-T therapy TAEST16001 developed by its subsidiary Xiangxue Life Sciences have been included in the list of breakthrough therapeutic varieties, and it is expected to become the first TCR-T listed. Xiangxue Pharmaceutical has also transformed from an old Chinese patent medicine enterprise into a leading company of advanced cell therapy, but the skyrocketing under the hype has come and gone quickly.

There are many incredible people, ideas and technologies in the field of innovative drugs, as well as a lot of hype. Therefore, the sense of separation and subversion is also increasing day by day.

However, the hype belongs to the hype, and the industry belongs to the industry. How is Xiangxue Pharmaceutical made? Behind this, how should we treat "innovation"?

01 innovative drugs are the most subversive.

When innovation becomes the main theme of the industry, transformation has become a top priority for all traditional pharmaceutical companies.

However, the opposition between tradition and innovation, and the gap between imitation and originality, most people think that traditional pharmaceutical companies have fallen behind, and no matter the size of enterprises, including big brother Hengrui Pharma, it is inevitable to ask: how can a generic drug maker make innovative drugs?

In particular, the listing of domestic PD-1 in 2018 and the opening of the two major exchanges to unprofitable biopharmaceutical companies, the whole capital and industry side, together pushed the innovative drug industry to the peak, and the field of innovative drugs was no different for a while, while traditional pharmaceutical companies once became the most desolate existence.

In fact, in the field of innovative drug research and development, traditional pharmaceutical companies have been slow, but it does not mean that they have completely lost opportunities.

Therefore, with the development of time, the transformation of some big pharmaceutical companies, such as Hengrui Pharma, Hansen Pharmaceutical and Unacon, is not smooth sailing, but it is natural because they have money and resources.

Subversion began when Baekje Shenzhou surpassed Hengrui and became the first brother of innovative medicine.

In 2022, the revenue of innovative drugs of the former surpassed that of the latter for the first time. This means that the leader of the domestic innovative drug market has changed hands. The young Baekje Shenzhou is still soaring, and its overall revenue may soon surpass that of Hengrui Pharma.

A number of new biotech faces have also begun to emerge. For example, in the emerging field of small nucleic acid drugs, Bowang Pharmaceutical, established in 2021, reached a cooperation with Novartis with a down payment of 185 million US dollars and a potential transaction of 4.165 billion US dollars to jointly develop a variety of cardiovascular siRNA drugs;

Yilian Bio, established in 2020, has successively reached cooperation with Roche and BioNTech with the story of its new generation ADC.

The research and development achievements of a new generation of biotech began to appear, which was expected by the market, because they were born for innovation.

The real subversion may be that a group of unscrupulous pharmaceutical companies have even begun to make medicines.

There was Bai Li Tian Heng, who was born in 2023. On December 12th, BL-B01D1, a dual-antibody ADC drug developed by Bailey Tianheng, was license out to Bristol-Myers Squibb with a total transaction amount of up to $8.3 billion.

This not only set a down payment record for the domestic innovative drug license out transaction, but also set a new record for the total price of the global ADC single drug transaction.

Who is Bai Li Tian Heng? Prior to this, its label was more "a Sichuan imitation pharmaceutical company".

Later, Xiangxue Pharmaceutical, the leader of A-share new cell therapy, rose by 227.5% in 11 trading days with the first overseas TCR-T therapy listed.

TAEST16001 injection developed by its subsidiary Xiangxue Life Sciences has been included in the list of breakthrough therapeutic varieties, and it is expected to become the first TCR-T cell therapy drug listed in China.

Who is Xiangxue Pharmaceutical? Prior to this, its label was more "anti-infective Chinese patent medicine enterprises". But this time, Xiangxue’s logic has changed, from an old Chinese patent medicine company to a leading company in advanced cell therapy.

Looking back, how did Xiangxue Pharmaceuticals make it?

How are the fragrant snows tempered?

Let’s look at Xiangxue Pharmaceutical first.

As an old Chinese medicine enterprise, it has neither the abundant internal resources of other big pharmaceutical companies nor the financial resources bought by buy buy willfully. How did a company relying on Chinese herbal medicines and oral liquid win the first domestic TCR-T therapy crown?

The story will start in 2012. At that time, Li Yi, a big cow in the field of cellular immunotherapy, returned to China to join the Guangzhou Institute of Biomedicine and Health of the Chinese Academy of Sciences and established a research platform, but he still needed to find a company to land.

When Li Yi worked in Avidex founded by Oxford University, he invented the guided evolution technology of TCR and used it to isolate and optimize the world’s first human-derived soluble TCR with high affinity, which opened the way for TCR to move from scientific research to clinical practice. Thanks to this key technological breakthrough, Immuncore, the leading company of TCR-T, has gradually developed from an early biotechnology company hatched by Oxford University to a company with multiple clinical products.

After returning home, by chance, Li Yi met Wang Yonghui, chairman of Xiangxue Pharmaceutical, and the two agreed to set up a life science research center and jointly establish a laboratory within Xiangxue Pharmaceutical.

Since 2013, Xiangxue Pharmaceutical has recruited scientists headed by Li Yi and Gong Haiping, which led to Xiangxue Life Science, which later became TCR-T.

In external reports, Xiangxue Pharmaceutical paid a price of 180 million yuan in five years for the promotion of TCR-T project. Among them, TAEST16001 has made the fastest progress. According to the wall newspaper data presented at this year’s ASCO meeting, as of April 2024, eight subjects were selected into the phase II clinical trial of TAEST16001, with the best remission rate of 50% and the median progression-free survival (mPFS) of 5.9 months.

From an industry perspective, the leading TCR-T company Immunocore, Adaptimmune, which just promoted the world’s first TCR-T therapy to be listed at the beginning of the month, and Xiangxue Life Sciences, the research and development teams of these three companies were actually one more than 10 years ago, that is, Avidex, where Li Yi worked.

From this point of view, several TCR-T products that are currently in the front line are only a few technologies transformed from the academic circles at that time, and they have landed in different countries and enterprises at the same time.

TCR-T is similar to CAR-T in mechanism. Compared with CAR-T, TCR is more similar to natural T cells in human body (CAR is only a fragment), which is not only safer, but also transmits stimulation signals to cells through TCR-CD3 complex. Therefore, TCR-T can not only identify antigens on tumor surface, but also identify antigens inside tumor. Therefore, TCR-T is more suitable for the treatment of solid tumors.

Even if it is a promising field, it needs practical results to prove its value. CAR-T therapy is widely known, largely thanks to successful cases like Emily’s, and then a variety of products have been listed one after another, opening a new era of cell therapy.

Although TCR-T therapy has great potential in theory, there is no product that really stands firm in the market.

Back to 12 years ago, not many companies were willing to spend hundreds of millions of dollars and continue to transfuse blood every year to bet on a track with uncertain future. Xiangxue has paid a lot for this. At present, the debt ratio of the company exceeds 70%, which is much higher than that of its peers such as Jichuan Pharmaceutical, which is about 20%.

Let’s look at Bai Li Tian Heng again.

Its development history can be traced back to 1996, when it started as a generic drug. At that time, Baili Tianheng’s predecessor, Baili Pharmaceutical, was established. Under the leadership of its founder, Yi Zhu, it launched the first generic drug, ribavirin granules, which once became a big single product.

Yi Zhu’s career is also "unusual". He majored in radio science, and later he got a master’s degree in biophysics from Fudan University and a doctor’s degree in corporate finance from Sichuan University. I have done real estate, set up Baili Pharmaceutical, and after taking the generic route, I took the sales team to fight in the front line.

Under the influence of drug quantity procurement and consistency evaluation, the company’s generic drug business revenue has been declining year by year, and the losses have been increasing. No one will believe that such a generic pharmaceutical company will make a name for itself in the field of innovative drugs. So, after the announcement of its deal with BMS, some people asked, who is Bailey Tianheng?

As early as 2008, Yi Zhu began to dabble in innovative drugs. Regrettably, after several years of tossing, many projects all failed.

However, he did not give up making innovative drugs. In 2014, he established an innovative pharmaceutical company in Seattle, Systimune. Ltd, which focused on the research and development of tumor drugs, and set up a research and development team.

At that time, Yi Zhu wrote a manuscript of the company’s plan for the next ten years: double antibodies, multi-antibodies and ADC drugs. At that time, the listing of TDM1 did not attract the attention of the industry. ADC drugs were at a low point in the United States, but he proposed to do double-antibody ADC.

It is believed that the toxicity problem of monoclonal antibody ADC has not been solved for the time being, and the uncertainty of dual antibody ADC will only be higher. However, Yi Zhu believes that technical problems can be solved, and it only takes time and investment: if there is a risk, strengthen the risk tolerance; If the resources are not enough, then think about how to get them back.

In June, 2023, Bailey Tianheng reported the first human clinical phase I research data of BL-B01D1 at ASCO meeting. BL-B01D1, which was not optimistic in 2014, was developed by Bailey Tianheng.

The results showed that the overall ORR was 45.3% when the median follow-up was 4.1 months, including 63.2% for EGFR mutant NSCLC, 44.9% for EGFR wild-type NSCLC and 53.6% for NPC patients.

It is such data that has contributed to its cooperation with BMS.

03 Tear off the "label"

In the eyes of the market, there may be only one truly smooth path for the transformation of generic pharmaceutical companies in China.

That is, to become a giant, after having a lot of resources, to acquire an already formed innovative drug system, or license in real innovative drugs, but most generic pharmaceutical companies are not enough.

The biggest argument for questioning the transformation of small-scale traditional pharmaceutical companies is that the development of new drugs abroad takes ten years and costs one billion dollars. A generic pharmaceutical company has a profit of only tens of millions of RMB a year. Why should it be a truly innovative drug?

Objectively speaking, such doubts are reasonable and normal. But it is this solidified way of thinking that increases the sense of separation and subversion in the field of innovative drugs.

For example, no matter Xiangxue Pharmaceutical or Baili Tianheng, we can see that the unscrupulous pharmaceutical companies can actually make innovative drugs.

Undeniably, there is a wave of speculation based on expectations behind Xiangxue Pharmaceutical’s stock price surge, and the clinical results are still unknown, and the skyrocketing speculation has come and gone quickly. In fact, its clinical data has also been questioned by some insiders, such as why the sample size is so small? How are 8 patients screened? Can you reproduce the same eye-catching data under the premise of increasing the number of overseas samples?

Everything has yet to be verified by time.

After the release of clinical data, Baili Tianheng was also questioned. When it reached a cooperation with BMS, it was regarded as a "dark horse" in the field of innovative drugs in China. It is also a medicine. After being endorsed by big pharmaceutical companies, the attitude of the market has changed rapidly.

Behind this, more is the role of "labels". Instead of directly judging the value of the drug itself, it is better to see who made it, who invested it and who bought it. Based on such a "label", it is easier to draw new and recognized conclusions.

Although it is important who made it and who bought it, even top researchers can’t violate the objective laws of the industry; Top multinational pharmaceutical companies can’t guarantee the success rate of every project and every transaction.

Perhaps, it is time for us to "label" thinking and treat "innovation" correctly.

In all fields, many times, things that others think can’t be done are not necessarily as difficult as they think. Just like the athletes who broke the monopoly of Europeans and Americans in this year’s Olympic Games, Pan Zhanle in swimming and queen Zheng Qinwen in tennis.

The same applies to the field of innovative drugs. There is no taking it for granted, and there is no impossibility. It is more a combination of necessity and accident.

Returning to the logic of innovative drug research and development, the achievements presented by Xiangxue Pharmaceutical and Baili Tianheng are, in essence, more a result of the innovative layout started 10 years ago; The key factor that determines how they will be three or five years later is the current layout and investment.

No matter whether it is biotech or traditional large pharmaceutical companies or small pharmaceutical companies, no one can succeed casually. It needs money, people and strategies, but also needs to advance and persist. What’s more, innovation is a divergent competition.

There is no absolute center for drug research and development, and the core depends on the efficacy of the product. The curative effect is determined by different principles and technical routes, and no one can monopolize and preset the results.

Because there is no fixed number of medicines.

　　CCTV News:After several months of investigation, the police in Xuanwei City, Yunnan Province recently destroyed an evil gang headed by the person in charge of the grassroots community. Recently, Yunnan police arrested seven suspects, including Qian Mou, deputy director of Liulin Community, in Liulin Community, Wanshui Street, Xuanwei City.

　　Chen Yuan, a policeman handling the case: "In 2017, from the end of June to the beginning of July, the public security organs kept receiving the person in charge of hauling coal ash from Xuanwei Power Plant, and went to the public security organs to report that their ash truck was blocked on the road many times and could not get into the power plant. Coal ash could not be pulled out. The most serious accident occurred in September, and the ash in ash storage has reached the warning line. If the ash is not pulled out in time, ash storage will explode, causing serious production accidents. "

　　Due to the urgency of the situation, Xuanwei City Public Security Bureau immediately set up a task force to investigate after receiving the alarm. After several months of in-depth and meticulous investigation, it was found that this seemingly simple contradiction and dispute between villagers and power plants actually hides a powerful behind-the-scenes pusher.

　　Chen Yuan, a policeman handling the case: "This incident was caused by Qianmou of Liulin Neighborhood Committee, who organized people to block the road for transporting coal and prevent the power plant from pulling coal ash to transport coal ash. His purpose is that the coal ash from the power plant can’t be pulled out, and then they organize people to pull it out and sell it to low-level cement plants to obtain certain economic benefits. "

　　There is a huge profit "black hand" hidden behind the coal ash waste residue.

　　Why do you want to organize people to compete for these humble coal ash residues? How much interest is there in it?

　　Chen Yuan, a policeman handling the case: "The total output of these coal ashes (from July to September, 2017) is about 20,000 tons, including the original water slag residue, which is 40,000 to 50,000 tons together. After he pulled all these things out and sold them, he gained more than one million economic benefits."

　　However, it is not a case that the power plant is blocked from production and operation like this. Zhang, who has worked in Xuanwei Power Plant for 20 years, told reporters that villagers in Liulin community and some unidentified people will come to block the power plant gates and office buildings from time to time, ranging from dozens to hundreds.

　　Xuanwei Power Plant Zhang: "Because of the historical reasons of our unit, the boundary is with their village. In this case, he often uses the excuse of pleading for the people to block the production and office area of the power plant. Their main person in charge put forward some exchange conditions for personal interests when talking about the project. For example, this problem of entering coal, taking engineering, and other things, as long as the power plant has contract business, he wants to do anything. "

　　Yang Tao, a policeman handling the case: "Through a large number of investigations in the early stage, we found that gangs headed by Qian Mou, in order to get the project from Xuanwei Power Plant and gain illegal benefits, incited people who didn’t know the truth to surround the gate of Xuanwei Power Plant for more than 40 times, blocked the normal traffic of vehicles in the area for more than 10 times, and disturbed the normal order for more than 20 times, which had a very bad impact on the normal production of enterprises and the lives of people around them."

　　The suspect admitted that the traffic jam was for economic benefit.

　　After the suspect arrived at the case, Xuanwei police conducted a trial according to law. At present, the suspect Qian confessed to the crime of blocking the power plant for profiteering.

　　Criminal suspect Qian: "We started to load the slag from the power plant at the end of June and load it to the cement plant. Because the water residue is waste, it has to be pulled to landfill. It is precisely the coal ash that falls on the coal yard and causes pollution. We thought that the power plant agreed to pull it anyway, and when it was pulled, there was a conflict of interest, and later a coal ash car was blocked. "

　　Inciting the masses to bully the city and village, involving many crimes.

　　With the advance of the trial, the criminal facts of this evil gang are becoming more and more clear. At present, there are still relevant criminal suspects coming to the case one after another. A further breakthrough has been made in the interrogation work. Combined with the investigation and evidence collection by the public security organs in the early stage, since October 2016, Qian has used his position to organize many people to manipulate security personnel in Liulin area, instructing villagers to make trouble and petition in the name of safeguarding the interests of the masses and representing their demands. Qian is mainly responsible for organizing, directing and leading a number of staff in Liulin community to bully the city within the community, and is suspected of intentional injury, destruction of production and operation, theft and other crimes, in which illegal income is kept by special personnel and used jointly by gang members.

　　Xu wen hua, a policeman handling the caseDuring the investigation, we also found that Liulin community recruited more than 40 idlers as security guards. These security guards were directly led and managed by Qian, deputy director of the neighborhood Committee. These security guards were not doing things for the people and protecting the safety of the people. They did whatever they wanted, and there were many incidents in which people were injured. One of the victims was still hospitalized. What’s worse, when the public security organs went to Liulin community to investigate and enforce the law, they not only did not cooperate, but even hindered the public security police.

　　victim: "I went home that night, and they were repairing the road. I discussed with them. My home arrived after this intersection, or I had to make a big detour. Can you let me pass, but the security guard disagreed? In the process of negotiation, a security guard rushed at me and threw me down. Then several people came up and beat me, and my leg was broken on the spot."

　　At present, seven suspects, including Qian, have been detained in criminal detention. It has been found that the gang is suspected of theft, sabotage of production and operation, and intentional injury, resulting in economic losses of millions of yuan. The case is still under further investigation.

　　Navigating for you in the ocean of information

　　China Radio International"China" series multilingual mobile clients are launched.

　　International Online Report (Reporter Yi Chengchen): On March 31st, three kinds of multilingual converged mobile clients "ChinaNews, ChinaRadio and ChinaTV" developed by China Radio International were released online. These three client products are characterized by multilingual and globalization, which can realize multilingual reading, listening and viewing, and provide intuitive, close and interactive all-media services for users around the world to understand China and the world. The release of "China" series of client products marks a new stage in the development of media convergence of China Radio International.

　　China Radio International, founded in December 1941, currently broadcasts to the world around the clock in 65 languages, making it the international communication organization with the largest number of languages in the world. In recent years, the international station has adhered to "multimedia integration and all-media development" and realized the transformation from external broadcasting to international communication.

　　In order to implement the spirit of the important speech of the Supreme Leader General Secretary, "Insist on advanced technology as the support and content construction as the foundation, and promote the deep integration of traditional media and emerging media in terms of content, channels, platforms, operation and management", and the central government’s media integration development strategy of "mobile priority", International TV follows closely the changes and development situation of international media, combines its own media characteristics, and integrates multilingual content resources around media construction and brand building to build an aggregated mobile. The "China" series of mobile client products released this time will rely on and strengthen the multilingual communication advantages of international stations to realize international communication based on the mobile Internet.

　　ChinaNews, a multilingual mobile news client, integrates the news resources of international stations, faces the international crowd, pushes hot news at home and abroad in real time by means of multilingual pictures, texts, videos and live broadcasts, interprets hot events from an authoritative perspective, and spreads the voice of China to the world with "first-hand information". It is a window for global users to pay attention to China and understand China, and it is also the spiritual home for overseas Chinese to love their motherland.

　　ChinaRadio, a multilingual mobile audio client, integrates multilingual audio program resources of international stations, takes multilingual audio programs as the main content and integrates multimedia communication means. This product is aimed at domestic and foreign users, providing live broadcast and on-demand services of multilingual radio programs, as well as various types of featured audio services covering information, music, entertainment, language learning and so on.

　　ChinaTV, a multilingual mobile video client, integrates video program resources of international stations, gathers cooperative media and third-party video news resources at home and abroad, and provides international news (video) reports and live video broadcasts of large-scale media activities for users all over the world. Gather multilingual video information content and broadcast programs of more than 300 domestic TV news programs, 140 live channels and three sets of digital TV channels (Global Shopping, Global Wonder and China Traffic Channel) of international TV stations; Show global quality documentaries, multilingual original videos produced by international stations and translated non-common language film and television programs. Strive to become a mobile video media window for overseas users to spread China culture.

　　Intelligent dispatch can also solve crimes.

Argus intelligent visual interactive system put into use in Minhang District, Shanghai, transmits pictures.

　　On the big screen, there is a real-time picture of the side of Zhongchun Road subway station in Minhang District, Shanghai. Ren Liangliang, vice president of Hellobike R&D, told the reporter that this is the Argus intelligent visual interactive system that was just put into use in Minhang District in May this year.

　　Based on image recognition technology, AI analysis and other technologies, the system can identify, intelligently judge and manage various bike-sharing and social vehicles in the area in real time, realize the dynamic balance among the total number of bicycles, riding demand and parking management, and help solve the problems of over-parking, random parking, vandalism and so on.

　　Ren Liangliang introduced that when the total number of bicycles in a certain area is too large, vehicles are parked out of bounds or parked indiscriminately, the system will automatically send orders to the operation and maintenance personnel for adjustment. "In the past, a point needed a fixed-point operation and maintenance personnel, but now it has become machine decision-making and intelligent dispatch. A fixed-point operation and maintenance personnel can manage seven to eight points nearby, greatly improving work efficiency; For government managers, it is possible to manage the city appearance of the area through macro video, judge whether the bicycle management in this area is neat, whether there are operation and maintenance personnel to follow up, and whether there are other uncivilized behaviors, and use technical means to reduce government management costs and improve government management efficiency. "

　　Sometimes the battery will be lost in the parking area. When the police file a case, they need to view the video frame by frame, which is like looking for a needle in a haystack, and the efficiency is very slow. The system of Harrow’s trip can help the police improve the efficiency of solving crimes.

　　Ren Liangliang explained from a better understanding point of view that if an algorithm is implanted in the system, as long as a person’s body is squatting or lying in a place for 30 seconds, it will be considered a suspicious behavior. Point out which video is suspicious when providing it to the police, and the police only need to confirm it for a few minutes.

　　The parking posture is wrong, please try again!

　　

Adaptive Bluetooth electronic fence independently developed by Hello.

　　Facing the problem of disorderly parking in bike-sharing, Hellobike has introduced the industry’s first application-level adaptive Bluetooth electronic fence to guide users to park in a specified area in an orderly manner and realize intelligent management of bicycle parking.

　　"When it is recognized that the bicycle is not parked in the designated area, the smart lock will automatically bounce off." Xing Shuai, a staff member of Hellobike, said that the success rate of sub-meter test of this technology has reached more than 95%, and it has been applied in more than 10 cities such as Shanghai and Nanchang.

　　Travel enterprises rely on technological innovation to make efforts in the application of big data, artificial intelligence, data analysis and other technologies, optimize travel configuration and improve travel efficiency, which can provide effective solutions for future traffic problems.

　　On August 29th, Hellobike officially released the latest iterative and upgraded intelligent system-"Hello Brain 2.0", which promoted the intelligent decision-making of full-link operation for two rounds of hello travel. Yang Lei, CEO of Hellobike, said that this marks that Hellobike has entered a new stage of two rounds of full-service intelligent operation, and artificial intelligence has become a powerful driving force for the development of two rounds of travel. Hello will continue to invest in artificial intelligence and continuously improve its independent research and innovation capability, with a view to playing a greater role in the future urban intelligent transportation construction.

　

Project overview

Mengcheng County No.2 Kindergarten Security Service Procurement Project (Secondary)Potential suppliers of should be inBozhou public resources transactionCentral website(http://ggzy.bozhou.gov.cn )obtainConsultation document, and in2025year05moon13sun09point00minuteSubmit the response document before (Beijing time).

　

I. Basic information of the project

1.Project number:BZMC2025CG031number

2.Task book number:FS34162220250096number

3.Project name:Mengcheng County No.2 Kindergarten Security Service Procurement Project (Secondary)

4.Purchasing method:Competitive negotiation

5.Budget amount:47.952ten thousand yuan/year

6.Maximum price limit:479520Yuan Dynasty (1206-1368)/year

7.Procurement demand:Mengcheng County No.2 Kindergarten Security Service Procurement Project (Secondary),See the competitive consultation document for details.

8.Term of performance of the contract:1095Calendar days, the contract is signed once a year.

9.This projectdisallowConsortium.

II. Qualification requirements of the applicant

1.Meet the provisions of Article 22 of the Government Procurement Law of People’s Republic of China (PRC)..

2.Qualification requirements for implementing government procurement policies;

This project is specially for small and medium-sized enterprises. According to the Administrative Measures for Government Procurement to Promote the Development of Small and Medium-sized Enterprises formulated by the Ministry of Finance and the Ministry of Industry and Information Technology, this project is a procurement project specially for small and medium-sized enterprises. The enterprise classification standard is in accordance with the notice on printing and distributing the provisions of the classification standard for small and medium-sized enterprises)(Ministry of Industry and Information Technology [2011〕300No.) regulations.

3.Specific qualification requirements for this project:

(one) In accordance with the Notice of the Ministry of Finance on Relevant Issues Concerning the Inquiry and Use of Credit Records in Government Procurement Activities (Treasury [2016〕125No), according to the review.“Credit China"Website (www.creditchina.gov.cn）、“China government procurement network"(www.ccgp.gov.cn) information, for suppliers who are included in the list of untrustworthy executors, major tax violations, and the record list of serious violations of government procurement, they are refused to participate in government procurement activities.

Note: According to the consultative group.Consultation documentIt is required to conduct interactive inquiry on bidders in the bid evaluation system, so as to compare the bid evaluation system of Bozhou public resources transaction with the bid evaluation system“Credit China (www.creditchina.gov.cn)"Real-time interactive data of the platform shall prevail. In case of system failure, it will be adopted by the consultation group.“Credit China (www.creditchina.gov.cn)"Manual inquiry shall prevail. If there is still a fault in manual inquiry, there is no requirement for this bid evaluation. The consultation team shall file screenshots of evidence on the fault page.

(2) packet division:Divided intooneA standard package, respectively:/.

(three) Other qualification requirements:The supplier must haveIssued by public security organsSecurity service license.(Valid certificate must be provided)

Third, accesspurchasedocument

1.Acquisition time:2025year04moon27Solstice2025year05moon07sun(The sale period of the consultation document is fromannouncementFrom the date of not less thanfiveWorking days)Every morning.eight o’clocktill/extremelytwelve o’clockIn the afternoontwelve o’clocktill/extremelyhalf past five p.m.(Beijing time, except legal holidays), the supplier must read it carefully.“Supplier qualification requirements", carefully participate.

2.Location of acquisition: please ask potential suppliers to obtain it at.Consultation documentLog in to Bozhou public resources transaction within the time limit.Central website(http://ggzy.bozhou.gov.cn )Electronic bidding trading platform, in accordance with the relevant procedures for participation (access, download competitive negotiation documents).

3.How to get it: useCALock on Bozhou electronic bidding trading platform to download.

4.Price of competitive negotiation documents: RMB per package.0Yuan, competitive negotiation documents are not returned after sale.

IV. Submission of response documents

1.Deadline for submission of response documents (consultation time):2025year05moon13sun09point00Minutes (Beijing time).

2.Location: The supplier shall pass before the deadline for bid opening.Electronic Bidding Trading Platform (Bozhou Public Resources Trading System)Submit electronic response documents; Response documents delivered after the deadline,The electronic bidding trading platform (Bozhou public resource trading system) will be rejected.

Five, open

1.Consultation time (same as the response)Deadline for submission):2025year05moon13sun09point00minute(Beijing time);

2.Consultation place:Mengcheng County Public Resource Trading Center (3rd floor, South Building, Smart City Center at the intersection of Renhe Road and Qishan Road, Mengcheng County, Bozhou City) (see the website of Bozhou Public Resource Trading Center for details of the bid opening room.“Bid opening schedule"Or the sign on the day of bid opening).

Sixth, the announcement period

As of the date of this announcementthreeWorking days.

VII. Other Supplementary Matters

(1) Submission of negotiation deposit: no negotiation deposit is charged for this project.

(B) competitive consultation announcement media

This competitive consultation announcement is posted on the Anhui Provincial Government Procurement Network (http://www.ccgp-anhui.gov.cn), Anhui Bidding Information Network (www.ahtba.org.cn), Bozhou Public Resource Trading Center website (http://ggzy.bozhou.gov.cn) and other media.

(3) service hotline

1.CADigital certificate and electronic signature consultation telephone number:4008804959

2.Electronic bidding technical support telephone number:4009980000

(4) Matters needing attention

1.This project only accepts the subject library of Anhui public resources trading market (hereinafter referred to as the subject library, the login address of the subject library of Anhui public resources trading market:https://ggzy.ah.gov.cn/ahggfwpt-zhutiku/dengludenglu) registered users who have passed the examination and approval can’t participate because they don’t go through the registration formalities in time, and they are responsible for it.

2.The person in charge of the unit is the same person or different suppliers with direct holding and management relations, and may not participate in government procurement activities under the same contract (bidding package). Except for single-source procurement projects, suppliers who provide overall design, specification preparation or project management, supervision and testing services for the procurement projects shall not participate in other procurement activities of the procurement projects.

3.For the government procurement projects of provincial purchasers, the supplier who wins the bid (clinches a deal) must become a registered user of Anhui provincial government procurement network supplier after winning the bid (clinches a deal) and before signing the procurement contract.

4.Obtain consultation documents

(one) Login address of the subject library of Anhui public resources trading market:https://ggzy.ah.gov.cn/ahggfwpt-zhutiku/dengludenglu) register users for free and handle related matters in accordance with relevant procedures.

(2) Click to fill in the bidding information, and download the competitive negotiation documents and other materials (including answering questions or relevant instructions) in a timely manner in accordance with the prescribed acquisition methods. If there are two or more tender packages in this project, potential suppliers must participate in the negotiation of any tender package online.

(three) Only after successfully downloading the competitive negotiation documents according to the prescribed acquisition method can all the participation procedures be completed. The online publishing system will be closed on time after the acquisition time (that is, the competitive negotiation acquisition time), and all potential suppliers must participate in and download the competitive negotiation documents in time. If the participation is invalid due to the failure to download the competitive consultation documents in time, the responsibility shall be borne by yourself. Based on the document acquisition confirmation form generated by Bozhou electronic bidding trading platform.

5.The competitive consultation document (electronic version) of this project is released at the same time with the competitive consultation announcement, only for all kinds of market subjects and the public to obtain the bidding information equally, quickly and accurately. If potential bidders (suppliers) are interested in bidding for this project, they must still log on to the website of Bozhou Public Resource Trading Center (http://ggzy.bozhou.gov.cn) The electronic bidding trading platform handles the downloading of competitive negotiation documents and other related matters. If it fails to do so within the time limit, it will be at its own risk.

6.In this project, the response document is submitted online, and the supplier decrypts the response document online without attending the bid opening on site.

7.This project supports suppliers to use government procurement contracts for credit financing.(Immediate policy and loan collection)The purchaser shall agree with the supplier on a unique collection account in the government procurement contract or by signing a supplementary agreement (name of the person in charge of the administrative loan collection business of Mengcheng Rural Commercial Bank: Ho Choi, Tel:18226126800）。

8. If you have any questions about this purchase, please contact us in the following ways.

1.Purchaser information

name 　Say:Mengcheng county 2 nd kindergarten

land 　Address:Bozhou cityWangyue Road, Chengguan Town, Mengcheng County98number

Contact information:0558-3062295

2.Purchasing agency information

name 　Say:Mengcheng county kunpeng project management co., ltd

land 　Address:South Third Floor, Nanhuayuan Complex, Intersection of Wangyue Road and Bacai Road, Mengcheng County, Bozhou City

Contact information:0558-7820098

3.Project contact information

Project contact:Director Cai、Wanggong

electricity 　　　　　Words:0558-3062295、0558-7820098

4.Questioning contact information

unite tie People:Director Cai and Wang Gong

Contact telephone number:0558-3062295、0558-7820098

　

　　At present, the snowfall in Hebei has basically stopped, but the cold wave has caused the temperature to continue to drop. From today (16th) to tomorrow, the minimum temperature in most parts of Hebei Province will continue to drop by 8 to 12℃, and the local temperature will drop by 12 to 16℃. In Xingtai City, heating enterprises adjust the heating parameters and water supply temperature, and complete the heating work of each heating station to ensure the heating temperature of residents’ homes.

　　Headquarters reporter Wang Shuainan:Today, the lowest temperature in Xingtai City reached 14 degrees below zero, and the highest temperature was only 6 degrees below zero. The snow cleared yesterday has been frozen very firmly today.

　　It is understood that there are currently four heat source enterprises in Xingtai City, which are responsible for the heating of 420,000 households in more than 1,000 communities. In view of the cold wave and low temperature weather, relevant departments made judgments in advance, launched emergency plans, urged heating enterprises to adjust heating operation parameters, improve the temperature of supply and return water, and do a good job in keeping warm and ensuring supply.

　　In the thermal intelligent operation center of Xingtai City, the reporter saw the real-time display of the operation status of various heat source enterprises in Xingtai City and the heating situation of the whole city on the big screen.

　　Chen Qiuhua, Deputy Director of Xingtai City Management Comprehensive Administrative Law Enforcement Bureau:At present, the heating system in Xingtai is running smoothly. In the next step, we will start the standby heat source according to the plan according to the weather conditions. In addition, 147 emergency rescue teams in Xingtai City are on duty 24 hours a day, ready to respond to emergencies and ensure the normal heating of residents.

　　Ningxia: Strengthening the "Vegetable Basket" Reserve to Ensure Market Supply

　　In the past few days, there have been cold waves, snowfall and windy weather processes in Ningxia. Ningxia’s commercial departments have strengthened monitoring and dispatching, strengthened reserves, and made every effort to ensure adequate supply of daily necessities such as vegetables, meat, eggs and milk, and stable prices.

　　In the comprehensive wholesale market of fresh agricultural products in Ningxia, the staff are busy unloading and moving goods.

　　It is understood that this is a large wholesale market of agricultural products in Ningxia, which bears 70% to 80% of the vegetable supply in Ningxia. At present, the daily supply of vegetables in the whole market is about 2,600 tons, which is basically the same as before the cold wave.

　　Zhao Jiangtao, Deputy General Manager of Ningxia Four Seasons Fresh Agricultural Products Comprehensive Wholesale Market:On the one hand, our market stores a certain amount of vegetables, and at the same time, our merchants also use their own large storage in the market and some warehouses around them. At present, this dynamic storage can guarantee the supply of vegetables within two weeks.

　　In a large supermarket in Ningxia, there is an endless stream of citizens who come to purchase. The store has rich varieties of vegetables and sufficient supplies of daily necessities such as meat, eggs and milk.

　　At present, the commercial department of Ningxia has started the daily monitoring mechanism of daily necessities market to monitor the inventory and price of daily necessities in all key wholesale markets and key retail enterprises, so as to ensure the abundant and stable prices of daily necessities market.

　　Shi Xinshan, the second-level director of the Market Operation and Consumption Promotion Department of Ningxia Department of Commerce:The autonomous region has 340 tons of frozen pork reserves and 400 tons of fresh beef and mutton reserves, which can be put into production at any time according to market demand. Six large wholesale markets and eight major retail enterprises now have 8,205 tons of vegetables in stock, which can meet the vegetable consumption of the people in the whole region for seven days. The daily necessities are also sufficient and the prices are stable, which can meet the basic needs of the people in the whole region.

　　Beijing: Strengthen maintenance, snow sweeping and ice shoveling to reduce the impact on train operation

　　The current snowfall in Beijing has stopped, but the outdoor temperature has continued to fall. In order to reduce the impact of snow and ice on train accessories, the workload of the staff in Beijing Depot of Beijing Railway Bureau has increased a lot these days. In addition to daily fine inspection and repair, there are also snow sweeping and ice shoveling work.

　　A train that has just completed the task of seeing off passengers from Beijing West Railway Station is slowly entering the whole station of Beijing West Passenger Station in Beijing Depot. After stopping, the staff immediately began to overhaul, including power supply system and braking system.

　　Ren Siyu, Deputy Director of Beijing West Library Inspection Workshop of Beijing Depot:In this (heavy snow) weather, our team’s maintenance time for each train has increased from about two hours before to three to four hours. Often, the train has not finished its homework, and a new train comes in again, which is equivalent to saying that it is running continuously.

　　At this time, the outdoor temperature was MINUS 4 degrees, and a lot of snow was piled up on the train body and roof, and the exposed parts were also covered with thick ice. If it is not cleaned in time, it will affect the various systems of the vehicle.

　　General desk reporter Wei Yured：Each train has an axle temperature sensor in each carriage, which can monitor the temperature of the train axle in real time. Through monitoring, the ground monitoring center can monitor the temperature of the axle in real time during the train operation to ensure the safety of the train operation. In the process of chiseling (ice), it can be clearly felt that this ice is actually very thick, and it takes some strength to remove it.

　　The train being overhauled has 15 carriages and 120 axle temperature sensors. It took nearly an hour to clean up this kind of accessories by knocking, scraping and beating in various ways. Axle temperature sensors are distributed near the wheels, which belong to ground operation. For those parts at the bottom of the train, it is more time-consuming and laborious to repair.

　　Yi Feng, inspector of Beijing West Library Inspection Workshop of Beijing Depot:Unit brake cylinder, which is an important accessory, is to ensure the release of our train, that is, the function of braking.

　　When working in the gutter, Feng Yi should always keep a bent posture. The unit brake cylinder at this point was covered with ice, and Yi Feng knocked it carefully with a hammer. After nearly an hour of operation, the unit brake cylinder of this train was finally checked.

　　In addition to the inspection outside the carriage, the inspection inside the car is also being carried out simultaneously.

　　Ren Zixuan, Vehicle Electrician of Beijing West Depot Inspection Workshop:The radiator inside the carriage, the cover and screws outside should not be loose, the shell should not be loose, and the radiator inside should be warm enough. The water boiler of the bus needs to ensure the water for passengers. After about one hour’s warm-up of our train in the garage, the temperature in the passenger room has reached the standard of leaving the warehouse.

　　After more than four hours of inspection, the train left from Beijing West Railway Station and went to Beijing West Railway Station to meet the passengers, ensuring that it departed from Beijing West Railway Station on time.

　　China Economic Net Beijing September 30 th (Reporter) Guo Yue) Yesterday, the State Administration of Market Supervision announced five recalls of passenger cars, and five brands including Toyota, BYD, Link, BMW and smart will recall a total of 233,612 vehicles. Among them, only Toyota brand recalled more than 100,000 vehicles.

　　Specifically, among the five passenger car brands that initiated the recall, Toyota has the largest number, and will recall a total of 132,124 vehicles, namely, Fenglanda twin-engine and Corolla sharp-release twin-engine vehicles, accounting for 56.56% of the total recall on that day.

　　The reason for the recall of the two models is that the brake actuator can not properly adjust the brake fluid pressure when braking during steering due to the imperfect computer program for controlling the brake actuator. In extreme cases, it may cause the vehicle to fail to provide braking force according to the driver’s intention for a very short time, and the braking distance is longer than the driver’s predicted distance, which increases the risk of vehicle collision and has potential safety hazards.

　　In this regard, GAC Toyota Motor Co., Ltd. and FAW Toyota Motor Co., Ltd. will upgrade the internal program of the brake actuator control computer for vehicles within the recall range free of charge to eliminate potential safety hazards.

　　BYD recalled 96,714 dolphins and Yuan PLUS, accounting for 41.40%. The reason for the recall is that due to the manufacturing process of the electric power steering column assembly (CEPS) controller, the upper cover of the equipment tool interferes with the capacitor on the controller circuit board when it is closed, resulting in microcracks in the capacitor. When the vehicle is in use, the micro-cracks of the capacitor may expand and cause short circuit, resulting in overheating, ablation and even fire of the capacitor, which poses a safety risk.

　　In this regard, BYD Auto Industry Co., Ltd. and BYD Auto Co., Ltd. will entrust BYD authorized dealers to install controller insulation gaskets for vehicles within the scope of recall free of charge to eliminate potential safety hazards.

　　In addition, Lectra announced the recall of 2,539 Lectra 08 vehicles; BMW announced the recall of 1,264 imported 5 Series, 7 Series, i5 and i7 vehicles; Smart will recall 971 Elf #3 pure electric vehicles.

The answer to this question depends on your personal needs and preferences. The following are some advantages and disadvantages of the two types of vehicles for your reference:

Twin-engine vehicle (hybrid vehicle):

Advantages:

* High fuel efficiency, which can save fuel cost.

* Low emission and environmental friendliness.

* The driving experience is usually smoother and quieter.

Disadvantages:

* The purchase cost is relatively high.

* Maintenance costs such as regular battery replacement may also be high.

Pure oil vehicles:

Advantages:

* The purchase cost is relatively low.

* No battery maintenance problems.

* Easier to repair and maintain.

Disadvantages:

* Fuel efficiency is relatively low, which may increase fuel costs.

* The impact on the environment may be greater.

Considering the future trend and environmental protection requirements, hybrid vehicles may be more popular and have long-term investment value. However, if you are more concerned about the cost of car purchase and the convenience of maintenance, pure oil vehicles may be more suitable for you. Therefore, it is suggested that you make comprehensive consideration according to your own needs and budget, and choose the most suitable vehicle type.

　　At 22: 00 on December 12, the Beijing Meteorological Observatory upgraded and issued an orange warning signal for blizzard. It is estimated that there will be heavy snow to snowstorm in Beijing from the morning of December 13th to the morning of 15th, with the strongest snowfall period from 10: 00 to 20: 00 on the 13th. The snowfall in Yanqing, Changping, Mentougou, Fangshan, Huairou, Haidian, Shijingshan, Fengtai, Dongcheng, Xicheng, Chaoyang, Daxing and Tongzhou will reach more than 10mm. The Municipal Emergency Bureau issued seven early warning and response measures.

　　Response Measures of Orange Warning for Blizzard in Beijing

　　1. Please pay attention to keep warm, prevent cold and freeze, and pay attention to the safety of fire, electricity and gas to prevent carbon monoxide poisoning.

　　2. Advocate citizens to travel less, and try to take buses and subways when traveling; Reduce driving trips, keep a safe distance and slow down when driving; Ride less or not ride bicycles and electric bicycles.

　　3. Please avoid visiting the mountains, and don’t go into the mountains unless necessary; Anti-skid measures should be taken when driving in mountainous areas; Stay away from old trees, structures, walls, plaques and dangerous areas of snow to prevent being crushed; When passing under the bridge and under the eaves, prevent the ice from melting and falling off and hurting people.

　　4. Primary and secondary schools and kindergartens implement home learning, carry out online teaching activities, and suspend classes without stopping learning; Advocate employees of enterprises and institutions to commute at peak hours and work flexibly.

　　5. All units should pay close attention to the weather changes, arrange production and business activities reasonably, and do not carry out outdoor operations and outdoor gathering activities unless it is necessary to ensure the normal operation of the city.

　　6. Urban operation guarantee units should fully carry out snow sweeping and ice shoveling, do a good job in heating service guarantee, strengthen traffic organization and guidance, pre-rescue emergency forces, timely handle emergencies, and ensure the safe operation of urban lifelines such as water, electricity, gas and heat.

　　7. It is necessary to closely monitor and promptly remove the snow on the top of various venues such as school gymnasiums, long-span buildings, agricultural facilities greenhouses, temporary structures and dangerous houses to prevent collapse. Mountain scenic spots are closed, and outdoor large-scale amusement facilities in non-mountain scenic spots are suspended.

　　Cctv newsAccording to official website, Beijing Administration of Traditional Chinese Medicine, at present, Beijing is in an influenza epidemic period, in which influenza A (H1N1) virus predominates and co-prevails with influenza A (H3N2) virus. The number of fever clinics in some medical institutions continues to increase, especially in pediatrics. In order to ensure the people’s demand for medical treatment and give full play to the characteristics and functions of traditional Chinese medicine scientifically, effectively, safely and steadily, the Beijing Municipal Administration of Traditional Chinese Medicine organized the Beijing Expert Group on Prevention and Treatment of Influenza with Traditional Chinese Medicine to formulate the Chinese Medicine Prevention and Treatment Plan for Spring Influenza in Beijing in 2023 (Trial).

　　The Beijing Municipal Administration of Traditional Chinese Medicine said that the health departments of all districts should organize experts to strengthen the guidance on the use of Chinese patent medicines, hospital preparations and Chinese medicinal decoction, especially referring to the catalogue of Chinese patent medicines attached to the prevention and control plan of Chinese medicine, and strengthen the publicity and guidance for patients, and guide patients to scientifically choose various Chinese medicinal preparations such as Chinese medicinal decoction and Chinese medicinal formula granules and substitute western medicine, Chinese patent medicines, hospital preparations and Chinese medicinal decoction. At the same time, the local medical institutions are urged to reserve and allocate relevant Chinese patent medicines and Chinese herbal pieces.

　　Beijing will strengthen the pediatric diagnosis and treatment services of traditional Chinese medicine, encourage qualified Chinese medicine medical institutions to open all pediatric clinics, and coordinate medical resources without excessively increasing the burden on medical staff, and open pediatric delayed clinics and night clinics to meet the medical needs in the peak period of epidemic. Encourage Chinese medical institutions (including Internet hospitals and medical institutions providing Internet diagnosis and treatment services) to prescribe online for influenza patients through the Internet diagnosis and treatment platform, and entrust qualified third parties to deliver medicines to patients’ homes. Encourage medical institutions to provide 24-hour online consultation services, and provide medical consultation, medication guidance and other services for influenza patients.

Recommended Catalogue of Chinese Patent Medicines Related to Influenza Treatment in Spring of 2023

Chinese Medicine Prevention and Treatment Scheme for Spring Influenza in Beijing in 2023 (Trial)

　　First, children’s influenza treatment prescription

　　【 Clinical manifestations 】 Acute onset, high fever, anhidrosis, body pain, sore throat, runny nose, cough, anorexia, nausea and vomiting, and dry stool. Red tongue, thick white or yellow fur, and floating pulse. The cough lingers after the fever has gone down.

　　1. Lung Wei Feng fever

　　[Treatment] Dispelling weathering and dampness, clearing away heat and toxic materials

　　[Basic Party]

　　Yinhua 10g Lianqiao 10g Huangqin 10g Cangshu 6g

　　Gypsum Fibrosum 15g (decocted first), Rhizoma Phragmitis 15g, Herba Agastaches 10g (later) and Fructus Arctii 6g.

　　Thin lotus 5g (bottom) Chenpi 6g raw malt 9g

　　One dose a day, decoction or granules, taken orally after meals: 3-6 years old, 50ml each time, twice a day; 6-14 years old, 100ml each time, twice a day; 14-18 years old, 200ml each time, twice a day.

　　[Chinese patent medicine] Children’s Ganmao Granules, Children’s Chiqiao Qingre Granules, Jinlian Qingre Effervescent Tablets, Qinxiang Qingjie Oral Liquid, Children’s Chaigui Antipyretic Granules, Children’s Resuqing Granules, etc.

　　2. Phlegm blocks the lung.

　　[Treatment] Dispelling lung heat, relieving cough and resolving phlegm

　　[Basic Party]

　　Roasted ephedra 3g bitter almond 6g gypsum 15g (fried first) orange stalk 3g.

　　Huangqin 6g Qianhu 10g Lianqiao 10g Gualou 10g

　　Fritillaria thunbergii 6g Houttuynia 10g (lower back) raw licorice 3g radish seed 9g

　　The decoction method is the same as above.

　　[Chinese patent medicine] Children’s cough liquid, children’s Xiaoji Zhike oral liquid, Feire Kechuan oral liquid, children’s Kechuanling oral liquid, Kaihoujian spray, Jinzhen oral liquid and so on can be selected based on syndrome differentiation.

　　Second, children’s influenza prevention prescriptions

　　Folium Isatidis 3g thin lotus 3g fried hawthorn 3g chrysanthemum 3g.

　　Chenpi 6g reed root 10g　　　

　　Decoct with water, one dose per day for 5 days.

　　Third, adult influenza treatment prescription

　　1. Wind-heat attack on table

　　【 Clinical manifestations 】 Fever or no fever, cough, red eyes, dry throat, sore throat, runny nose, thirst, red tongue with thin yellow coating and rapid pulse.

　　[Treatment] Dispelling wind and clearing heat

　　[Basic Party]

　　Silver flower 15g upturned 15g burdock 15g Schizonepeta spike 9g

　　Thin lotus 6g (lower back), mulberry leaf 15g, chrysanthemum flower 15g and Scrophularia 15g

　　Bitter almond 10g Fritillaria thunbergii 10g reed root 30g raw licorice 6g

　　Decoct with water, one dose a day.

　　[Chinese patent medicine] Jinhua Qinggan Granule, Sangju Ganmao Tablet

　　2. Wind-cold bundle table

　　【 Clinical manifestations 】 aversion to cold, fever, head and body pain, cough, white phlegm, thin and white tongue coating and tight pulse.

　　[Treatment] Dispel wind and cold

　　[Basic Party]

　　Baked ephedra 6g bitter almond 10g cassia twig 10g kudzu root 15g

　　Qiang Huo 10g Su Ye 10g (lower back) Jing Jie 10g Bai Zhi 10g

　　Radix Glycyrrhizae preparata 6g

　　Decoct with water, one dose a day.

　　[Chinese patent medicine] Ganmao Qingre Granule, Jiuwei Qianghuo Pill

　　3. Wind-heat invading the lungs

　　【 Clinical manifestations 】 High fever, red throat and sore throat, red eyes and eyelids, thirst and thirst, cough, red tongue with yellow coating, and slippery pulse.

　　[Treatment] Clearing away heat and toxic materials, dispersing lung qi and removing pathogenic factors.

　　[Basic Party]

　　Roasted ephedra 6g bitter almond 9g gypsum 30g (fried first) Zhimu 10g

　　Reed root 30g burdock 15g Fritillaria thunbergii 10g Huangqin 10g　

　　Lonicera japonica Thunb. 15g Artemisia sphaerocephala Thunb. 10g Radix Glycyrrhizae 6g.

　　Glehnia littoralis 15g

　　Decoct with water, one dose a day.

　　　　　　 [Chinese patent medicine] Jinhua Qinggan Granule, Lianhua Qingwen Capsule

　　4. exterior cold and interior heat

　　【 Clinical manifestations 】 aversion to cold, high fever, headache, body aches, sore throat, red throat, stuffy nose and runny nose, thirst, red tongue, thin coating and rapid pulse.

　　Treating exterior syndrome and clearing interior syndrome

　　[Basic Party]

　　Roasted Ephedra 6g Cinnamomum cassia twig 10g Qiang Huo 10g Gypsum Fibrosum 30g (fried first)

　　Huangqin 15g Zhimu 10g Chishao 15g Roasted Glycyrrhiza 6g

　　Decoct with water, one dose a day.

　　[Chinese patent medicine] Jinhua Qinggan Granule, Lianhua Qingwen Capsule

　　5. Pathogenic accumulation in lung and stomach

　　【 Clinical manifestations 】 Fever, aversion to cold, nausea, vomiting, abdominal distension, abdominal pain and diarrhea, and head and body aches. The tongue is red, thick and greasy with fur, and the pulse is slippery.

　　[Treatment] Clearing lung and stomach, eliminating dampness and harmonizing middle energizer.

　　[Basic Party]

　　Pueraria lobata 15g Huangqin 15g Huanglian 10g Cangshu 15g

　　Huoxiang 10g (bottom) Jiang Banxia 9g perilla 10g thick plain 10g.

　　Bitter almond 9g white peony 12g licorice 6g

　　Decoct with water, one dose a day.

　　[Chinese patent medicine] Gegen Qinlian micro pill, Huoxiang Zhengqi preparation, etc.

　　6. Poisonous gas camp

　　【 Clinical manifestations 】 High fever, cough, chest tightness, shortness of breath, dysphoria, even delirium, obstructed stool, crimson tongue, yellow fur and rapid pulse.

　　[Treatment] Clearing qi, cooling camp, dredging fu organs and inducing resuscitation.

　　[Basic Party]

　　Roasted Ephedra 9g Bitter Almond 9g Gualou 30g Raw Rhubarb 10g (lower back)

　　Gypsum 45g (fried first), red peony 15g, buffalo horn 30g and silver flower 15g

　　Lianqiao 15g Ginseng 15g (decocted separately) Zhimu 10g

　　Decoct with water, one dose a day.

　　[Chinese patent medicine] Angong Niuhuang Pill, Tanreqing, Xuebijing, Qingkailing, Xingnaojing injection, etc.

　　Fourth, adult influenza prevention

　　1. Trollius 3g, mint 3g, raw licorice 3g, instead of tea.

　　2. Those who are susceptible to cold can use ginger 10g and jujube 5g instead of tea.

　　V. Nursing care

　　1. Pay attention to climate change and increase or decrease clothes at any time.

　　2. Try to go to places where people gather as little as possible, wear masks, ventilate the room and wash your hands frequently.

　　3. Drink more warm water after suffering from the flu, have a light diet and keep the stool unobstructed.

　　4. The elderly, pregnant women, infants, obese people and people with chronic diseases should seek medical advice immediately after suffering from influenza.Under the guidance of a doctor, choose Chinese medicine for syndrome differentiation and treatment..