Wen | amino observation

In the world of innovative medicine, the most important thing is the story of subversion.

From Baekje Shenzhou to Hengrui Pharma, it became the first innovative medicine, and then to the strong rise of domestic CAR-T and ADC, subversion continued.

In the innovative medicine camp, a group of unscrupulous pharmaceutical companies have even begun to make medicines. This may be subversive.

For example, Bailey Tianheng, which was born at the end of last year, set the world’s largest BD for ADC with a total transaction volume of 83 US dollars. People are surprised that a small imitation pharmaceutical company in Sichuan can also make a unique pipeline in the world?

For another example, Xiangxue Pharmaceutical, which has been popular recently, and the TCR-T therapy TAEST16001 developed by its subsidiary Xiangxue Life Sciences have been included in the list of breakthrough therapeutic varieties, and it is expected to become the first TCR-T listed. Xiangxue Pharmaceutical has also transformed from an old Chinese patent medicine enterprise into a leading company of advanced cell therapy, but the skyrocketing under the hype has come and gone quickly.

There are many incredible people, ideas and technologies in the field of innovative drugs, as well as a lot of hype. Therefore, the sense of separation and subversion is also increasing day by day.

However, the hype belongs to the hype, and the industry belongs to the industry. How is Xiangxue Pharmaceutical made? Behind this, how should we treat "innovation"?

01 innovative drugs are the most subversive.

When innovation becomes the main theme of the industry, transformation has become a top priority for all traditional pharmaceutical companies.

However, the opposition between tradition and innovation, and the gap between imitation and originality, most people think that traditional pharmaceutical companies have fallen behind, and no matter the size of enterprises, including big brother Hengrui Pharma, it is inevitable to ask: how can a generic drug maker make innovative drugs?

In particular, the listing of domestic PD-1 in 2018 and the opening of the two major exchanges to unprofitable biopharmaceutical companies, the whole capital and industry side, together pushed the innovative drug industry to the peak, and the field of innovative drugs was no different for a while, while traditional pharmaceutical companies once became the most desolate existence.

In fact, in the field of innovative drug research and development, traditional pharmaceutical companies have been slow, but it does not mean that they have completely lost opportunities.

Therefore, with the development of time, the transformation of some big pharmaceutical companies, such as Hengrui Pharma, Hansen Pharmaceutical and Unacon, is not smooth sailing, but it is natural because they have money and resources.

Subversion began when Baekje Shenzhou surpassed Hengrui and became the first brother of innovative medicine.

In 2022, the revenue of innovative drugs of the former surpassed that of the latter for the first time. This means that the leader of the domestic innovative drug market has changed hands. The young Baekje Shenzhou is still soaring, and its overall revenue may soon surpass that of Hengrui Pharma.

A number of new biotech faces have also begun to emerge. For example, in the emerging field of small nucleic acid drugs, Bowang Pharmaceutical, established in 2021, reached a cooperation with Novartis with a down payment of 185 million US dollars and a potential transaction of 4.165 billion US dollars to jointly develop a variety of cardiovascular siRNA drugs;

Yilian Bio, established in 2020, has successively reached cooperation with Roche and BioNTech with the story of its new generation ADC.

The research and development achievements of a new generation of biotech began to appear, which was expected by the market, because they were born for innovation.

The real subversion may be that a group of unscrupulous pharmaceutical companies have even begun to make medicines.

There was Bai Li Tian Heng, who was born in 2023. On December 12th, BL-B01D1, a dual-antibody ADC drug developed by Bailey Tianheng, was license out to Bristol-Myers Squibb with a total transaction amount of up to $8.3 billion.

This not only set a down payment record for the domestic innovative drug license out transaction, but also set a new record for the total price of the global ADC single drug transaction.

Who is Bai Li Tian Heng? Prior to this, its label was more "a Sichuan imitation pharmaceutical company".

Later, Xiangxue Pharmaceutical, the leader of A-share new cell therapy, rose by 227.5% in 11 trading days with the first overseas TCR-T therapy listed.

TAEST16001 injection developed by its subsidiary Xiangxue Life Sciences has been included in the list of breakthrough therapeutic varieties, and it is expected to become the first TCR-T cell therapy drug listed in China.

Who is Xiangxue Pharmaceutical? Prior to this, its label was more "anti-infective Chinese patent medicine enterprises". But this time, Xiangxue’s logic has changed, from an old Chinese patent medicine company to a leading company in advanced cell therapy.

Looking back, how did Xiangxue Pharmaceuticals make it?

How are the fragrant snows tempered?

Let’s look at Xiangxue Pharmaceutical first.

As an old Chinese medicine enterprise, it has neither the abundant internal resources of other big pharmaceutical companies nor the financial resources bought by buy buy willfully. How did a company relying on Chinese herbal medicines and oral liquid win the first domestic TCR-T therapy crown?

The story will start in 2012. At that time, Li Yi, a big cow in the field of cellular immunotherapy, returned to China to join the Guangzhou Institute of Biomedicine and Health of the Chinese Academy of Sciences and established a research platform, but he still needed to find a company to land.

When Li Yi worked in Avidex founded by Oxford University, he invented the guided evolution technology of TCR and used it to isolate and optimize the world’s first human-derived soluble TCR with high affinity, which opened the way for TCR to move from scientific research to clinical practice. Thanks to this key technological breakthrough, Immuncore, the leading company of TCR-T, has gradually developed from an early biotechnology company hatched by Oxford University to a company with multiple clinical products.

After returning home, by chance, Li Yi met Wang Yonghui, chairman of Xiangxue Pharmaceutical, and the two agreed to set up a life science research center and jointly establish a laboratory within Xiangxue Pharmaceutical.

Since 2013, Xiangxue Pharmaceutical has recruited scientists headed by Li Yi and Gong Haiping, which led to Xiangxue Life Science, which later became TCR-T.

In external reports, Xiangxue Pharmaceutical paid a price of 180 million yuan in five years for the promotion of TCR-T project. Among them, TAEST16001 has made the fastest progress. According to the wall newspaper data presented at this year’s ASCO meeting, as of April 2024, eight subjects were selected into the phase II clinical trial of TAEST16001, with the best remission rate of 50% and the median progression-free survival (mPFS) of 5.9 months.

From an industry perspective, the leading TCR-T company Immunocore, Adaptimmune, which just promoted the world’s first TCR-T therapy to be listed at the beginning of the month, and Xiangxue Life Sciences, the research and development teams of these three companies were actually one more than 10 years ago, that is, Avidex, where Li Yi worked.

From this point of view, several TCR-T products that are currently in the front line are only a few technologies transformed from the academic circles at that time, and they have landed in different countries and enterprises at the same time.

TCR-T is similar to CAR-T in mechanism. Compared with CAR-T, TCR is more similar to natural T cells in human body (CAR is only a fragment), which is not only safer, but also transmits stimulation signals to cells through TCR-CD3 complex. Therefore, TCR-T can not only identify antigens on tumor surface, but also identify antigens inside tumor. Therefore, TCR-T is more suitable for the treatment of solid tumors.

Even if it is a promising field, it needs practical results to prove its value. CAR-T therapy is widely known, largely thanks to successful cases like Emily’s, and then a variety of products have been listed one after another, opening a new era of cell therapy.

Although TCR-T therapy has great potential in theory, there is no product that really stands firm in the market.

Back to 12 years ago, not many companies were willing to spend hundreds of millions of dollars and continue to transfuse blood every year to bet on a track with uncertain future. Xiangxue has paid a lot for this. At present, the debt ratio of the company exceeds 70%, which is much higher than that of its peers such as Jichuan Pharmaceutical, which is about 20%.

Let’s look at Bai Li Tian Heng again.

Its development history can be traced back to 1996, when it started as a generic drug. At that time, Baili Tianheng’s predecessor, Baili Pharmaceutical, was established. Under the leadership of its founder, Yi Zhu, it launched the first generic drug, ribavirin granules, which once became a big single product.

Yi Zhu’s career is also "unusual". He majored in radio science, and later he got a master’s degree in biophysics from Fudan University and a doctor’s degree in corporate finance from Sichuan University. I have done real estate, set up Baili Pharmaceutical, and after taking the generic route, I took the sales team to fight in the front line.

Under the influence of drug quantity procurement and consistency evaluation, the company’s generic drug business revenue has been declining year by year, and the losses have been increasing. No one will believe that such a generic pharmaceutical company will make a name for itself in the field of innovative drugs. So, after the announcement of its deal with BMS, some people asked, who is Bailey Tianheng?

As early as 2008, Yi Zhu began to dabble in innovative drugs. Regrettably, after several years of tossing, many projects all failed.

However, he did not give up making innovative drugs. In 2014, he established an innovative pharmaceutical company in Seattle, Systimune. Ltd, which focused on the research and development of tumor drugs, and set up a research and development team.

At that time, Yi Zhu wrote a manuscript of the company’s plan for the next ten years: double antibodies, multi-antibodies and ADC drugs. At that time, the listing of TDM1 did not attract the attention of the industry. ADC drugs were at a low point in the United States, but he proposed to do double-antibody ADC.

It is believed that the toxicity problem of monoclonal antibody ADC has not been solved for the time being, and the uncertainty of dual antibody ADC will only be higher. However, Yi Zhu believes that technical problems can be solved, and it only takes time and investment: if there is a risk, strengthen the risk tolerance; If the resources are not enough, then think about how to get them back.

In June, 2023, Bailey Tianheng reported the first human clinical phase I research data of BL-B01D1 at ASCO meeting. BL-B01D1, which was not optimistic in 2014, was developed by Bailey Tianheng.

The results showed that the overall ORR was 45.3% when the median follow-up was 4.1 months, including 63.2% for EGFR mutant NSCLC, 44.9% for EGFR wild-type NSCLC and 53.6% for NPC patients.

It is such data that has contributed to its cooperation with BMS.

03 Tear off the "label"

In the eyes of the market, there may be only one truly smooth path for the transformation of generic pharmaceutical companies in China.

That is, to become a giant, after having a lot of resources, to acquire an already formed innovative drug system, or license in real innovative drugs, but most generic pharmaceutical companies are not enough.

The biggest argument for questioning the transformation of small-scale traditional pharmaceutical companies is that the development of new drugs abroad takes ten years and costs one billion dollars. A generic pharmaceutical company has a profit of only tens of millions of RMB a year. Why should it be a truly innovative drug?

Objectively speaking, such doubts are reasonable and normal. But it is this solidified way of thinking that increases the sense of separation and subversion in the field of innovative drugs.

For example, no matter Xiangxue Pharmaceutical or Baili Tianheng, we can see that the unscrupulous pharmaceutical companies can actually make innovative drugs.

Undeniably, there is a wave of speculation based on expectations behind Xiangxue Pharmaceutical’s stock price surge, and the clinical results are still unknown, and the skyrocketing speculation has come and gone quickly. In fact, its clinical data has also been questioned by some insiders, such as why the sample size is so small? How are 8 patients screened? Can you reproduce the same eye-catching data under the premise of increasing the number of overseas samples?

Everything has yet to be verified by time.

After the release of clinical data, Baili Tianheng was also questioned. When it reached a cooperation with BMS, it was regarded as a "dark horse" in the field of innovative drugs in China. It is also a medicine. After being endorsed by big pharmaceutical companies, the attitude of the market has changed rapidly.

Behind this, more is the role of "labels". Instead of directly judging the value of the drug itself, it is better to see who made it, who invested it and who bought it. Based on such a "label", it is easier to draw new and recognized conclusions.

Although it is important who made it and who bought it, even top researchers can’t violate the objective laws of the industry; Top multinational pharmaceutical companies can’t guarantee the success rate of every project and every transaction.

Perhaps, it is time for us to "label" thinking and treat "innovation" correctly.

In all fields, many times, things that others think can’t be done are not necessarily as difficult as they think. Just like the athletes who broke the monopoly of Europeans and Americans in this year’s Olympic Games, Pan Zhanle in swimming and queen Zheng Qinwen in tennis.

The same applies to the field of innovative drugs. There is no taking it for granted, and there is no impossibility. It is more a combination of necessity and accident.

Returning to the logic of innovative drug research and development, the achievements presented by Xiangxue Pharmaceutical and Baili Tianheng are, in essence, more a result of the innovative layout started 10 years ago; The key factor that determines how they will be three or five years later is the current layout and investment.

No matter whether it is biotech or traditional large pharmaceutical companies or small pharmaceutical companies, no one can succeed casually. It needs money, people and strategies, but also needs to advance and persist. What’s more, innovation is a divergent competition.

There is no absolute center for drug research and development, and the core depends on the efficacy of the product. The curative effect is determined by different principles and technical routes, and no one can monopolize and preset the results.

Because there is no fixed number of medicines.

　　　　　　　　Before "Running Brothers 2" (hereinafter referred to as "Running Man 2") was aired, Zhejiang Satellite TV was reluctant to disclose the complete feature content to its customers. Even at their huge advertising investment promotion meeting, they just invited a group of people to secretly watch the clips of the samples.

　　　　　　　　Wow! Is Zhejiang Satellite TV so awesome? Compared with "Running Man 1", taking samples everywhere for comments, it is now hidden deeply. Is it a blockbuster?

　　　　　　　　As it turns out, I was wrong. After watching the premiere of Running Man 2 on Friday night, I realized why Zhejiang Satellite TV didn’t dare to expose it in advance.

　　　　　　　　To tell my conscience, I was angry after watching the first episode of Running Man 2 for about 1 hour and 23 minutes-it was completely damaging the brand of Running Man. In terms of program production, this episode is not up to standard.

　　　　　　　　Why do I say this?

Playing with concepts? Play without rhyme or reason

　　　　　　　　I still don’t understand what this issue has to do with "Saint saint seiya" until I watched the "commercial acknowledgment" at the end of the program.

　　　　　　　　Isn’t it because Fan Bingbing and Han Geng are coming? Don’t you just want to make two goddesses PK? So I arranged a suspense plot of "Finding True and False Athena" throughout the whole process. However, I was really drunk when I saw the special effects of fifty cents and the so-called "battle shirt" that seemed to smell plastic.

　　　　　　　　The most crossing is this one: Angelababy is sitting in the bus, wearing the shirt of Athena, holding an Apple 6plus mobile phone, and chatting with Bao Beier. -is it necessary to make it so neither fish nor fowl?

　　　　　　　　In addition to the smelly and long 10-minute introduction of the main creator, at the end, Fan Bingbing and Angelababy wore the "crown" at the same time and ordered the title of "Looking for Athena". In the core game of the program, the concept of feelings of Saint saint seiya was not strong at all. After 90 s and 00 s who didn’t catch up with saint seiya, I don’t know how they feel when they see these uncles and aunts playing an entry-level cosplay.

Strong guests, you can’t make a good table.

　　　　　　　　According to the truth, the men’s running team plus Fan Bingbing Han Geng, this lineup is a big attraction. But what’s presented in the program, I think that’s all.

　　　　　　　　Let’s talk about the new "running men’s group" first.

　　　　　　　　Wang Baoqiang couldn’t record Running Man 2 because of the schedule, so Bao Beier took the opportunity to substitute. I was deeply impressed by Bao Beier’s performance in the first issue of Running Man 2: in the Mud Field War, he jumped to become the "King of Leaks"; When fighting with Han Geng, he performed a "Zhao Si Dance" which was not very brilliant. Maybe it’s the running-in. I didn’t see too many highlights in this issue.

　　　　　　　　Except Bao Beier, other members of the "Running Men’s Team" performed well.

　　　　　　　　Deng Chao, whether pleading with Fan Bingbing or coquetry at the children in front of the TV, the style of "teasing" remains the same; In Michael Chen, I can’t see that I have experienced a marriage storm at all, and I am still funny; Jerry Lee is also very hard-working, and it hurts both Fan Bingbing and Fan Bingbing. Emotion and reason coexist; Ryan still maintains the previous route and cares for the baby all the time, and may still choose to "wait and give up"; Compared with the first season, Wong Cho Lam is more open and natural in this program, and some "baggage" can hit the punch line.

　　　　　　　　Finally, there is Angelababy. Before the program started, her agent company asked the media everywhere not to write too much about her loss to Fan Bingbing. "Same sex is friends", which seems to really mind. However, after watching the program, I actually praised Angelababy’s sense of self-humiliation and strong ownership.

　　　　　　　　Yes! Members of the men’s running team are so good, but why can’t they make a good table? The problem lies in the guests who come. From waiting in line with Angelababy, to grabbing a gourd ladle, and then to playing the game of catching chickens, Fan Bingbing’s competitive spirit is undoubtedly revealed. Coupled with the humility of those running men, this program lost the spirit of "running men". -you are a guest, you are a goddess, I will let you? What do you think!

　　　　　　　　Look, as soon as the program was finished, an article came out, "On the road of women, there is a gap of 100 Jia Ling between Angelababy and Fan Bingbing". To be honest, I don’t know whether Fan Bingbing’s performance is good or not, but Angelababy won’t be so bad.

Tearing famous brands, when is there only manual labor left?

　　　　　　　　Game links, has always been "Running Man" program is the highlight. However, in terms of game links, this program simply lowers the gold content of the "Running Man" series.

　　　　　　　　From beginning to end, there are only three large-scale game links.

　　　　　　　　Put something in the mud field, let the stars climb up, and whoever laughs last within the specified time will win. As a warm-up session, it is understandable. At least you can see the stars make a fool of themselves.

　　　　　　　　The next game link is-the star puts on a tricky shape and lets the competitors imitate it. Whoever imitates wrong will lose. To be honest, the difficulty coefficient of this link is really not high. After a game, I guess I didn’t sweat. It is not a clever thing to amuse the audience by body.

　　　　　　　　Finally! It is the audience’s expectation and the core of the program that the "tearing famous brands" war is coming. As a result, it was actually fun-"the eagle catches the chicken." Hey! You are an outdoor reality show, okay? Are the two teams playing this game in the indoor hall worthy of the audience who stay in front of the TV at night?

　　　　　　　　I know some people will say that the program group is helpless in this arrangement. Because when recording in Chengdu, many people were watching. For the sake of safety, we had to give up the original settings, and finally chose the "eagle catches chicken" link to complete the recording of the program … Don’t talk so much! An interactive game, is it difficult to shoot more? The tearing of famous brands, which originally embodied intelligence, was replaced by "fighting physical strength".

　　　　　　　　I don’t know what Xia Chen ‘an, the former director of Zhejiang Satellite TV, would think if he saw that the "tearing famous brands" link that was once publicly praised was now interpreted like this.

　　　　　　　　Let’s say one last word. If the Running Man series wants to go on, it should not only ensure the wonderful plot setting, but also avoid compromising with foreign forces. Running Man is Running Man, not an advertising platform for Everything Growing.

　　　　　　　　That’s it.　

CCTV News:On May 17th, a number of heavy policies supporting real estate were released: explicitly canceling the lower limit of the national mortgage interest rate policy, lowering the mortgage down payment ratio and provident fund loan interest rate, and planning to set up affordable housing refinancing. Industry experts said that the adjustment of housing finance policy exceeded expectations and sent a clear signal to stabilize the real estate market.　

The People’s Bank of China and the State Financial Supervision and Administration issued a notice that the minimum down payment ratio of the first and second home loans should be reduced to not less than 15% and not less than 25% respectively.

Yin Zhongli, director of the Real Estate Finance Research Center of the Institute of Finance of China Academy of Social Sciences, said: "The down payment ratio has dropped to 15%, which is the lowest down payment ratio in history. The adjustment of the down payment ratio and the lower limit of interest rate policy will have obvious effects on incremental housing. "　

The central bank announced the cancellation of the lower limit of the interest rate policy for the first and second home loans at the national level, and lowered the interest rate for individual housing provident fund loans. Industry insiders predict that after the implementation of the policy, the mortgage interest rate in most cities may drop by 0.3— 0.4 percentage points. According to the method of 1 million yuan loan, 30-year term and equal principal and interest repayment, the total interest expenditure can be reduced by more than 70 thousand yuan.

Experts said that the adjustment of the housing financial policy was stronger than expected, which sent a clear signal to stabilize the real estate market. "After the introduction of the policy package of the People’s Bank of China, it will meet the policy expectations of buyers to a certain extent and is expected to form a real estate market. ‘ Policy bottom ’ " .

Revitalizing existing housing is the key to resolving real estate risks. The People’s Bank of China newly set up a loan of 300 billion yuan for affordable housing to support local state-owned enterprises to purchase completed unsold commercial housing at a reasonable price, and use it as allotment-type or rent-type affordable housing. State-owned enterprises in Zhengzhou, Nanjing, Zhuhai and other places have tried first, and participated in the destocking of existing housing through direct acquisition and trade-in.

Shaanxi: The interest rate of individual housing provident fund loans will be lowered from now on.

After the central bank announced on May 17 that it would lower the interest rate of individual housing provident fund loans, Shaanxi, Henan and other places immediately followed suit. On May 17th, Shaanxi Housing Fund Management Center issued the Notice on Lowering the Loan Interest Rate of Individual Housing Provident Fund (hereinafter referred to as the Notice), which will be implemented from May 18th.

According to the Notice, since May 18, 2024, the interest rate of individual housing provident fund loans will be lowered by 0.25 percentage point, and the interest rates of the first set of individual housing provident fund loans for less than five years (including five years) and more than five years will be adjusted to 2.35% and 2.85% respectively, and the interest rates of the second set of individual housing provident fund loans for less than five years (including five years) and more than five years will be adjusted to 2.775% and 3.325% respectively.

The "Notice" also clarifies that the new interest rate standard will be implemented from January 1, 2025 for individual housing provident fund loans that have been issued before May 18 with a loan term of more than one year. Personal housing provident fund loans that have been accepted but not issued before May 18 will be subject to the new interest rate standard when issued.

Jeikiy, director of the Finance Department of the Housing Provident Fund Management Center in Xi ‘an, Shaanxi Province, introduced that according to the repayment method of principal and interest equal to the first loan, with a 30-year period and a maximum loan of 650,000 yuan for a single employee, the interest can be saved by more than 30,000 yuan; According to the maximum loan amount of 850,000 yuan for dual employees, the interest can be saved by more than 40,000 yuan; For families with many children, the maximum loan of 1.02 million yuan can save interest expenses by nearly 50 thousand yuan. Superimposed mortgage down payment policy, the purchase mode of "low down payment+low commercial loan interest rate+low provident fund interest rate" will better play the role of housing provident fund in safeguarding people’s livelihood.

Before the interest rate of personal housing provident fund loans was lowered this time, on May 10th, Shaanxi Housing Fund Management Center issued the Notice on Adjusting Relevant Policies of Housing Provident Fund Loans, in which the down payment ratio of using provident fund loans to purchase houses, the loan period for purchasing second-hand housing and the maximum loan amount for families with two or more children were adjusted.

Henan: Lowering the interest rate of personal housing provident fund loans only requires high enthusiasm for crowd consultation.

Zhengzhou, Henan Province also lowered the interest rate of individual housing provident fund loans by 0.25 percentage points from the 18th. The reporter saw in the Guancheng District Administrative Service Center of Zhengzhou City that many citizens came to consult and handle the "business-to-public" business of personal housing loans.

The reporter learned in an interview with Guancheng District Administrative Service Center that the number of citizens who came to consult and handle the "business-to-public" business of personal housing loans has increased significantly recently, and the number of business consultations and handling in the last week has accumulated more than 1,000.

On October 28, 2024, it was officially listed, and four models were launched, with the price range of 24,900 yuan to 39,900 yuan. At this conference, Pentium Pony cooperated with the well-known IP "Pony Baoli" for the first time, which attracted many women and children to participate in the interaction. This cross-border joint name is not only the first cooperation between Xiaoma Baoli and a car company, but also the first video joint name, which further enhances the attraction of the event.

The four models launched this time are: 122km cute horse, priced at 24,900 yuan; 170km energetic horse, priced at 31,900 yuan; 222km smart horse, priced at 36,900 yuan; And 222km lightning horse, priced at 39,900 yuan. In addition, Pentium Pony also announced a series of preferential policies for car purchase to attract more consumers.

Pony Baoli is a well-known IP for girls launched by Hasbro Company in 1980s. Its core concept revolves around dreams, creativity, kindness, courage and self-confidence. These images are highly compatible with the brand positioning of Pentium Pony. Pentium pony used many capsule lines in its design, incorporating the front and rear bumpers, the contrasting decorative parts of the side doors and the interior details. This design is inspired by the capsule car in the famous animation, and the Pentium pony shows the childhood dream in its unique way.

In terms of design, the Pentium pony abandoned the traditional square box design and adopted streamlined elements. The body size was 3000mm x 1510mm x 1630mm, and the overall shape was round and full, with smooth curves. The front face was designed with a contrast grille, which made it more lovely and attractive. In terms of interior, this new car adopts a "dessert"-like color scheme, and the layout of the shift knob is designed on the dashboard, so the user does not need to bow his head when operating, which is convenient and safe. At the same time, the brake pedal and the switch pedal are designed with music "pause" symbol and game "acceleration" symbol respectively, which adds interest.

In terms of battery life and performance, Pentium Pony also performed well, providing the longest battery life of 222km in its class, and upgrading the fast charging function, which can increase the battery life by 100km after charging for 1 hour. It is equipped with a 30kW high-power motor, which has stronger power performance and more flexible starting to meet the needs of daily travel.

Since its listing in May this year, Pentium Pony has continued to sell well, with sales exceeding 10,000 units in September, which is widely loved by trendy moms, fashionable women and families with children. With the price close to the people and relatively low maintenance cost, Pentium pony has become an ideal means of transportation for daily short-distance travel. If you are considering a scooter, Pentium Pony is undoubtedly a worthy choice.

　　Jiangsu, China Network August 17th Nanjing News (National Health) Every time the urgent telephone rings, it means that a race against time is about to start for emergency doctors. August 19th is the first Physician’s Day in China. Following the footsteps of a 120 emergency doctor, the reporter recorded the first-aid day in a race against time and life, and felt the ups and downs in her work and life.

　　Liu Shengsheng is 36 years old. After graduating from medical university, he came to work in Nanjing and settled down in Nanjing. At the end of 2013, she wanted to challenge herself and apply to Nanjing Emergency Center to become an ordinary emergency doctor.

　　half past seven

　　When the reporter rushed to the West Emergency Sub-station of Nanjing Emergency Center, Liu Shengsheng, who had gone to work at 8: 00, had changed into white work clothes, and was as heroic as a female soldier, close to 1.7 meters, with short hair and a bit of sunshine, freedom and vitality. After completing the OA system login, she began to carefully check the first-aid drugs and medical equipment to see if the drugs need to be added, check whether the oxygen is enough and whether the medical equipment is in good condition … After some preparatory work, it was 7: 50, just close to work time.

　　three past eight

　　"Ding-ding-ding", a sudden ringing of the mobile phone broke the silence. Liu Shengsheng received an instruction from the dispatching command center: Lhasa Road, a 67-year-old man suspected of having a stroke and needed emergency rescue. Liu Shengsheng rushed out of the door in turn with emergency equipment and crew members.

　　At this time, the ambulance honked all the way and arrived at the patient’s community in 8 minutes. During the driving process, Liu Shengsheng has contacted his family by phone to inquire about the patient’s situation, to reassure them that the ambulance will arrive soon, and to ask his family to bring medical insurance cards and medical records. This is what Liu Shengsheng must do every time he leaves the car. As soon as the car stopped, Liu Shengsheng carried medical equipment, picked up the first aid kit and held the stretcher. The three men ran to the fourth floor in one breath. Because the patient lives in an old community, he is panting and sweating when he goes upstairs. Enter the patient’s home, check the vital signs by ECG, blood pressure, etc., then carry the patient to the ambulance and send him to the provincial people’s hospital for further treatment.

　　After handing over the patient to the hospital, Liu Shengsheng came out first, got into the car, picked up the tablet computer, and filled in the patient’s electronic medical record and driving information. The reporter tried to pick up the medical equipment that Liu Shengsheng had just carried, which weighed 10 kilograms. At this time, Liu Shengsheng was like a "female man". In the car, the reporter saw that the clothes on her back were completely attached to her body because of the soaking of sweat.

　　five past nine

　　The dispatching command center received an alarm from the public. A middle-aged woman on Caochangmen Street was injured by cycling and needed treatment.

　　Not long after returning to the site, Liu Shengsheng, who was sorting out the car-related records, rushed out with his colleagues. After arriving at the site for inspection, it was found that the injured person’s waist and right limb could not move, and it was suspected that there was a fracture. Liu Shengsheng comforted the patient’s emotions. After fixing the injured person’s right leg with the nurse, he used a special shovel stretcher to carry the injured person to the ambulance and take him to the hospital.

　　twenty five to eleven

　　There is a fracture patient in a hospital in Xuanwu District who needs to be transferred for treatment. When they arrived at the hospital, Liu Shengsheng and the stretcher bearers pushed the stretcher to the patient’s floor. After the handover with the doctors in the hospital, they fixed the patient on the stretcher and put him on the ambulance. This is a "first aid" for Liu Shengsheng.

　　twenty past twelve

　　It was noon when they returned to the substation. On standby, they trotted all the way to the canteen to cook. On the way, there were not many words between them, and their faces were full of fatigue. "Take advantage of the gap to cook quickly, and the canteen will be closed later. Maybe the car will leave in the next second." Liu Shengsheng said that although beginning of autumn was gone, it was still very hot at noon, and ambulances were called most often at this time. It was common to leave the car in the middle of eating. The last time he had lunch, it was already 3 or 4 o’clock in the afternoon, and sometimes he could only eat some fruits brought from home. Sure enough, the work phone rang again before the meal was finished.

　　fifteen to one p.m./a quarter to one p.m.

　　"Excuse me, is your home in Longjiang District? Tell someone to wait downstairs, and we’ll be right there. " Liu Shengsheng got on the ambulance while calling back to confirm the patient’s location. The helper is a woman, saying that the old mother’s heart is uncomfortable, and she can’t get up in one breath, and her family members are very anxious. On the way, the patient’s family called again to urge, and the ambulance running all the way arrived in Longjiang Community 10 minutes later.

　　The patient’s home is on the fifth floor. The patient is sitting on the sofa and in poor health. Liu Shengsheng immediately gives oxygen to the patient, checks his heart rhythm, and the nurse measures his blood pressure and gives him infusion. Looking at the patient inhaling oxygen, the family members breathed a sigh of relief. They said: "At that time, when I called, the situation was particularly critical. My old mother felt chest tightness and couldn’t get up in one breath. She almost fainted."

　　It is understood that the patient has diabetes and high blood pressure for several years and has no heart disease. After on-site treatment, Liu Shengsheng, together with the nurse, pushed the patient downstairs with a stretcher. On the way to the hospital, the family members were anxious, and Liu Shengsheng kept comforting the patients and their families until the handover with the hospital was completed.

　　ten past two p.m.

　　After seeing the patient off, she left the Provincial Hospital of Traditional Chinese Medicine. On the way, Liu Shengsheng fell asleep with her head leaning against the window with her tablet computer and first aid notebook in her hand … The reporter didn’t have the heart to bother her again.

　　twenty four to four p.m.

　　There was a traffic accident on Qingliangmen Street, and some people were injured. Close to the scene, I saw a young man waving a sun hat in the distance. He was a passer-by. When he saw a car accident, he offered to help. Sweating all over his face, he said to the emergency personnel, "I like you, and I came here in 6 minutes." Liu Shengsheng is busy dressing the wounded, the nurse holds the wounded, and the stretcher bearer pushes the stretcher to stand by. After carrying the patient to the ambulance, Liu Shengsheng took the initiative to help the patient contact his family and explain the relevant situation. On the way to the hospital, the reporter saw Liu Shengsheng take out a paper towel to help the injured gently wipe the blood from the corner of his eyes.

　　twenty three past five p.m.

　　An old man in Jinji apartment suffered from diarrhea for a long time. When Liu Shengsheng arrived at the old man’s home, he found that the old man had been suffering from severe diarrhea with vomiting for a day and was weak. In addition, the old man was 87 years old, and new illness might occur at any time. She took the initiative to help the old man wipe off the urine and vomit, and carried the old man to the ambulance with a soft stretcher with the stretcher.

　　seven to seven p.m.

　　When the reporter was ready to leave, Liu Shengsheng received a phone call from the dispatching command center. "An old man fell and was suspected of having a femoral neck fracture." "Go, get out of the car." I saw that she picked up the medicine cabinet and quickly rushed to her own battlefield …

　　Liu Shengsheng’s day is just a microcosm of many emergency doctors in Nanjing. For the vast number of emergency personnel, every day is a "life and death" speed contest! Regardless of spring, summer, autumn and winter, regardless of the heat and cold, they stick to the concept of "time is life", shuttle through the streets and lanes, rush about for one life in a difficult environment and exhausted struggle, and appreciate the lofty value of saving lives.

　 　　

　 　 1905 movie network news "Welcome to Hainan Island, a’ China Hawaii’ with blue sky and blue sea. Young and energetic Sao men and women are bathing in the sunshine and playing by the sea. With the advancement of the camera, beautiful girls with high values are tied to the beach, and handsome men in the sunshine are kneeling on the ground and digging for sand. English narration reveals the details of the program — — Beauty and Beast is harmonious and wonderful. Wait, there seems to be something wrong. Let’s fall back again. It is obviously "Beauty and Best" (school flower and learning god)! "

　

　 　 Yes, you are watching the trailer of China’s first youth reality show, Super-burning and High-pressure International Edition, which will be launched soon, and it is recommended by the budding "crooked fruit" (foreign) friends who really love the show. "School Beauty and Learning God" will be broadcast on CCTV-6 at 20: 15 every Sunday night from April 12th. Don’t miss it!

　

The first exposure of the "Tearing Hips" war highlights, the players bluntly said, "Please learn to be a man before making a show."

　

　 　 Recently, the program group just exposed the lineup of six big coffee star tutors from Xia Yu, Xiao Qiang, Yang Wei, Laure Shang, Hawick Lau and Zray, and "School Flower and Learning God" quickly launched an international trailer with high-grade atmosphere and Chinese and English subtitles, which captured the eye again. According to the arrangement of the competition system of "School Beauty and Learning God", each episode will compete through the dual mode of competitive competition and film answering questions, and at the end, a pair of male and female players will be eliminated. The cruel test makes the students have to go all out in every link and never relax. On the one hand, it tests everyone’s teamwork ability, on the other hand, it also depends on everyone’s emotional intelligence and social ability.

　

　 　 So the spoiler came! The trailer is dubbed with a different kind of "sour and refreshing" voice, which gives us a glimpse of the wonderful "tearing (si) crotch (bi)" tidbits in the competition process in advance. There are many explosive "golden sentences" — — "First of all, she is acting", "In fact, everyone is not stupid", "Learn to be a person before putting on a show" and "I just don’t like you. Do you need a reason" … … Among them, Li Yang, a god-learning player, blushed and stood up, shouting "It is absolutely impossible to insult others’ personality!" The picture appears. In the end, we can only look forward to the launch of "School Beauty and Learning God" to see what efforts 32 college students have made to finally win the 1 million Dream Foundation, and whether their friendship can stand the test in the cruel knockout.

　

The sense of cold comics makes the laughter fly to school to learn the gods’ "confession" in front of the camera.

　

　 　 "School Beauty and Learning God" does not hide its willful temperament of "youth", and the whole preview sword is biased, playing with comics and feeling man show amorous feelings. The narration read by "crooked nuts" (foreigners) also hides all kinds of wonderful jokes from time to time — — For example, if you are not careful, you will become a Study God who studies God. For example, if you don’t have a Chinese foundation, you will never understand Huyoued (plus ED); Another example is "I don’t look good on camera" = without-makeup beauties. All right, young lang, the subtitle group has been working hard. Remember to watch the program and don’t laugh too presumptuously.

　

　 　 However, the willfulness of these subtitle groups is definitely not as ambiguous as the ambiguous paragraphs. When Duan Chao said "I met my little Zhao Wei today" to the camera, when the school girls were ashamed to say "the first impression" of the most handsome boy in front of the camera, when the school girls couldn’t help giving each other a "love hug" after the competition. This simple and green ambiguous element of "AUO over lover not full" really makes people see the fawn bumping into each other.

　

　 　"School Beauty and Learning God" is another key seasonal reality show launched by the film channel, and this time it has been joined by the main team of South Korea. Xue Shen, who finally won the championship, will receive a large amount of venture capital, while the winner of the school flower is an international co-production film contract. The program will be broadcast on CCTV-6 at 20:15 every Sunday night from April 12th. Audiences over 40 years old, please watch with young people!

Three major US stock indexes overnightMixed up and down,S&P 500 indexIt fell 1.39% to 5588.27 points.Nasdaq composite indexIt fell 2.77% to 17,996.92 points.Dow Jones industrial averageIt rose by 0.59% to 41,198.08 points.

Among the US stocks overnight,A total of 97 Chinese stocks rose and 173 Chinese stocks fell..

Popular Chinese stocksAmong them, Alibaba fell by 1.70%, Pinduoduo by 2.96%, Netease by 0.03%, JD.COM by 0.81%, Baidu by 2.82%, New Oriental by 2.17%, Bili by 3.54% and iQiyi by 2.40%.

New forces of building carsAll fell, LI fell by 2.82%, Weilai fell by 6.33% and Xpeng Motors fell by 3.91%.

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　　Reading tips

　　Some research shows that slow charging is one of the core pain points for users of new energy vehicles to replenish energy. Since the beginning of this year, many places have successively issued policies to speed up the construction of overcharging stations. However, the construction of over-charging station is facing some problems, such as insufficient grid power, high investment cost, long payback period, few charging models and difficult compatibility. Industry insiders suggest that it is necessary to promote cooperation and exchanges between upstream and downstream enterprises in the industrial chain, promote cooperation between new energy automobile manufacturers, charging facility operators and other related enterprises, and jointly promote the construction of "overcharged city".

　　"I saw on the small program that it can be charged here, so I stopped by and it was fully charged in less than 10 minutes." Recently, Mr. Mi experienced the super fast charging of new energy vehicles for the first time in the Changzhen service area of Shenzhen Expressway in Guangming District, Shenzhen, and repeatedly lamented that it was very fast and convenient.

　　"One kilometer per second", "One cup of coffee, full charge" … … Recently, many places across the country have proposed to build a "city of overcharging", intensively introduced relevant policies, and accelerated the construction of overcharging stations.

　　Has the era of overcharge of new energy vehicles arrived? In this regard, industry insiders told the Workers Daily reporter that the application of overcharge technology will bring many changes to the market and consumers. However, at present, the construction of overcharge stations still faces problems such as insufficient grid power, high investment cost, long payback period, few charging models, and difficulty in compatibility. It is necessary to work together to strengthen industrial cooperation, optimize the layout of charging networks, and establish special subsidies for the construction of overcharge equipment.

　　Slow charging is the pain point of recharging.

　　"New energy vehicles are accelerating penetration. However, at present, the charging operation service is mainly based on ordinary DC fast filling piles, and the charging time is relatively long." Chen Tianshun, general manager of Shenzhen Bus New Energy Co., Ltd. introduced.

　　Mr. Mai, a citizen of Shenzhen, is a loyal fan of new energy vehicles, but considering the convenience of travel, he chose a hybrid vehicle. He admits that if the number of over-filled piles is enough and it is easy for mobile phones to find, he will consider switching to pure electric vehicles.

　　According to the research of Yiou think tank, in the charging mode of new energy vehicle users, slow charging accounts for over 50%. When charging with public fast-charging piles, the proportion of charging time longer than 40 minutes is as high as 44%, which is also one of the core pain points for users to replenish energy. 84% of users have expressed their approval attitude towards overcharge, and the market expectation is high.

　　With the popularization of new energy vehicles, it is the future trend to overcharge and replenish energy. Since the beginning of this year, many places have successively introduced policies to speed up the construction of overcharging stations. Recently released "Special Plan for Overcharging Facilities of New Energy Vehicles in Shenzhen (2023-2025)" (hereinafter referred to as the plan) once again sounded the clarion call for the construction of "Overcharging City" in Shenzhen. According to the plan, by the end of 2023, no less than 150 public overcharging stations will be built in Shenzhen; By the end of March 2024, no less than 300 public overcharging stations will be built.

　　It’s not just Shenzhen that is accelerating the construction of "Overcharged City". For example, Beijing has publicly solicited opinions on the construction and operation incentives for charging and replacing facilities. Among the operating incentives for public charging facilities, the maximum subsidy for over-charged piles is 216 yuan/kilowatt year; Guangzhou launched the "Super Charging Capital" plan, clearly supported the super high-power fast charging technology, and made great efforts to build a multi-level, multi-category and multi-scenario charging system; Hainan initiated the construction plan of "Overcharged Island", and proposed to build over 400 overcharged stations … …

　　Refueling charging experience

　　"The power is from 20% to 90% in 30 minutes." Mr. Gao, a citizen of Shenzhen, will go to Jingtian Wal-Mart Super Charging Station every weekend to charge, plug in a charging gun, go into the supermarket to buy some daily necessities, and when he comes out, he will be fully charged, and he can park for free with the charging record.

　　"One kilometer per second" gives consumers a refueling experience. According to Shenzhen Power Supply Bureau of China Southern Power Grid, compared with ordinary 60 kW charging piles, the charging speed of super-charged piles is 10 times as fast as that of ordinary piles.

　　The main difference between overcharging, fast charging and slow charging lies in the difference of output voltage and current. Talking about the highlights of overcharging technology, Han Tao, vice president of Shenzhen Yingfeiyuan Technology Co., Ltd. Group, said that overcharging and fast charging are high-power DC charging, and the overcharge charging power is generally above 360kW. Overcharging 480kW can increase the battery life by 250 kilometers in 5 minutes and can be fully charged in 10 minutes; Fully charge 80% of the electricity within one hour; Slow charging basically takes one night to fill. The charging guns used by the three are also different. Only liquid-cooled guns can be used for overcharging, which greatly reduces the difficulty of the owner’s operation, while the conventional guns for fast charging and slow charging are thicker and heavier.

　　The reporter learned that Futian Shenkang Super Charging Station, jointly built by Shenzhen Bus New Energy Co., Ltd. and Shenzhen Yingfeiyuan Technology Co., Ltd., integrates photovoltaic station, energy storage station and electric vehicle charging and discharging station, realizing "multi-station integration".

　　Still face many problems.

　　Does it mean that the era of overcharging is about to open? The interviewed enterprises all said that the construction of overcharged equipment still faces pain points, mainly reflected in the lack of power grid, high investment cost, long payback period, few charging models, difficult compatibility and insufficient charging infrastructure.

　　"Overcharging equipment is more technically difficult, which requires not only higher charging power and faster charging speed, but also safety and reliability. Therefore, it is necessary to upgrade the power grid, increase the energy storage system and invest more money. At the same time, a large number of vehicles are needed to improve the utilization rate of overcharged equipment in order to achieve the expected benefits of the site. " Han Tao bluntly said that there are not many models supporting overcharge on the market at present, and the development of overcharged vehicles lags behind the development of overcharged equipment. The overcharge compatibility of different models is also different, which requires different interfaces and power. At present, the "Chaoji" charging standard has just been released, and it will take time to implement it.

　　In view of the problem that there are few models supporting overcharge in the market at present, Chen Tianshun believes that from the industrial point of view, it is necessary to speed up the technical iteration of overcharge models in the process of promoting the construction of overcharge stations, so that more models can be compatible with overcharge efficiency. On the other hand, it is also hoped that the relevant government departments can give certain policy subsidies to enterprises that build overcharged stations.

　　Regarding how to promote the further landing of overcharged stations, Han Tao believes that it is necessary to promote cooperation and exchanges between upstream and downstream enterprises in the industrial chain, promote cooperation between new energy automobile manufacturers, charging facility operators and other related enterprises, and jointly promote the construction of "overcharged city". At the same time, enterprises and research institutions are encouraged to strengthen the research and development and innovation of overcharge technology to enhance the scientific and technological content and competitiveness of charging facilities.